Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 2/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.47 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.47 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HBB | P68871 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21915928 | 1.00 | ADRA2C (0.48) | ADRA2CCHRM5ADRA2AADRA2BADRA1D | |
| SCHEMBL19749861 | 1.00 | ADRA2C (0.48) | ADRA2CCHRM5ADRA2AADRA2BADRA1D | |
| SCHEMBL18638041 | 1.00 | ADRA2C (0.48) | ADRA2CCHRM5ADRA2AADRA2BADRA1D | |
| SCHEMBL6577437 | 1.00 | ADRA2C (0.48) | ADRA2CCHRM5ADRA2AADRA2BADRA1D | |
| SCHEMBL3357474 | 1.00 | ADRA2C (0.48) | ADRA2CCHRM5ADRA2AADRA2BADRA1D | |
| SCHEMBL334715 | 1.00 | ADRA2C (0.48) | ADRA2CCHRM5ADRA2AADRA2BADRA1D | |
| SCHEMBL18769020 | 1.00 | ADRA2C (0.48) | ADRA2CCHRM5ADRA2AADRA2BADRA1D | |
| SCHEMBL335246 | 0.97 | — | — | |
| SCHEMBL16274766 | 0.90 | TP53 (0.42) | ADRA2CCHRM5ADRA2AADRA2BADRA1D | |
| SCHEMBL608892 | 0.87 | HRH3 (0.48) | ADRA2CCHRM5ADRA2AADRA2BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220135544-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | ASTEX THERAPEUTICS LTD (GB) | 2022-05-05 | — | — | US | disclosed |
| US-10272087-B2 | Pteridines as FGFR inhibitors | ASTEX THERAPEUTICS LTD (GB) | 2019-04-30 | — | — | US | disclosed |
| EP-3141633-B1 | COPPER PLATING BATH COMPOSITION | ATOTECH DEUTSCHLAND GMBH (DE) | 2018-05-02 | — | — | EP | disclosed |
| US-9850228-B2 | Pyrazolyl quinoxaline kinase inhibitors | ASTEX THERAPEUTICS LTD (GB) | 2017-12-26 | — | — | US | disclosed |
| US-9757364-B2 | Naphthyridine derivative compounds | ASTEX THERAPEUTICS LTD (GB) | 2017-09-12 | — | — | US | disclosed |
| US-9737544-B2 | Compounds | ASTEX THERAPEUTICS LIMITED (GB) | 2017-08-22 | — | — | US | disclosed |
| US-20170105978-A1 | NEW COMPOUNDS | ASTEX THERAPEUTICS LIMITED (GB) | 2017-04-20 | — | — | US | disclosed |
| EP-3141633-A1 | COPPER PLATING BATH COMPOSITION | ATOTECH Deutschland GmbH (DE) | 2017-03-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170105978-A1 | NEW COMPOUNDS | NQO1, NTPCR, NDC1 | ADRA2C 1087/4885CHRM5 3952/4885ADRA2A 2600/4885 |
| US-10272087-B2 | Pteridines as FGFR inhibitors | FGFR1, FGFR3, FGFR2 | ADRA2C 4250/4885CHRM5 4357/4885ADRA2A 4475/4885 |
| US-20220135544-A1 | PYRAZOLYL QUINOXALINE KINASE INHIBITORS | PDXK, DCK, PDPK1 | ADRA2C 2726/4885CHRM5 3827/4885ADRA2A 3350/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.