Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18643117 | 0.87 | SNCA (0.41) | LMNASNCAKMT2ACNR1 | |
| SCHEMBL18643353 | 0.79 | FAAH (0.49) | ALDH1A1LMNATP53THRBHTT | |
| SCHEMBL892451 | 0.73 | SNCA (0.74) | SNCAKMT2APOLB | |
| SCHEMBL18639761 | 0.72 | ALOX15 (0.41) | ALDH1A1LMNAKDM4EHTTKMT2A | |
| SCHEMBL18856076 | 0.69 | SNCA (0.57) | LMNASNCAKDM4ENPC1RAB9A | |
| SCHEMBL15932072 | 0.67 | RAB9A (0.58) | ALDH1A1NPC1RAB9AKMT2APOLB | |
| SCHEMBL892772 | 0.65 | SNCA (0.74) | SNCA | |
| SCHEMBL15931718 | 0.65 | ALDH1A1 (0.58) | ALDH1A1LMNATP53KDM4ENPC1 | |
| SCHEMBL892102 | 0.63 | SNCA (0.73) | SNCA | |
| SCHEMBL15956476 | 0.63 | MRGPRX4 (0.61) | ALDH1A1LMNATP53KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440550-B1 | INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES | UNIV LEUVEN KATH (BE) | 2017-03-15 | — | — | EP | disclosed |