SCHEMBL18645205 — predicted protein targets

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	HTR6	P50406	5/20	0.55

▸	FEN1	P39748	1/20	0.46

▸	JAK2	O60674	1/20	0.43

▸	JAK1	P23458	1/20	0.43

▸	BCHE	P06276	3/20	0.43

▸	HPGDS	O60760	2/20	0.41

▸	ACKR3	P25106	1/20	0.41

▸	PRMT5	O14744	3/20	0.40

▸	FNTA	P49354	1/20	0.40

▸	FNTB	P49356	1/20	0.40

▸	CYP2C9	P11712	1/20	0.40

▸	PARP1	P09874	2/20	0.39

▸	PARP2	Q9UGN5	2/20	0.39

▸	USP30	Q70CQ3	2/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL18645213	0.86	HTR6 (0.47)	HTR6JAK2JAK1BCHEHPGDS
SCHEMBL18645206	0.84	HTR6 (0.53)	HTR6FEN1BCHEHPGDSACKR3
SCHEMBL18644664	0.83	JAK2 (0.49)	HTR6JAK2JAK1HPGDSPARP1
SCHEMBL18818205	0.79	HRH3 (0.39)	HTR6PRMT5
SCHEMBL18289976	0.79	HTR6 (0.40)	HTR6JAK2JAK1HPGDSPRMT5
SCHEMBL18818206	0.79	HRH3 (0.39)	HTR6PRMT5
SCHEMBL30111801	0.79	HTR6 (0.40)	HTR6JAK2JAK1HPGDSPRMT5
SCHEMBL16341186	0.78	HTR6 (0.46)	HTR6JAK2JAK1BCHEHPGDS
SCHEMBL15171260	0.78	HTR6 (0.46)	HTR6JAK2JAK1BCHEHPGDS
SCHEMBL18645204	0.77	ACKR3 (0.49)	HTR6JAK2JAK1BCHEACKR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2017041536-A1	OXO-DIHYDROIMIDAZO PYRIDINE COMPOUND AND APPLICATIONS THEREOF	东莞市真兴贝特医药技术有限公司	2017-03-16	—	—	WO	disclosed