Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 4/20 | 0.47 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 2/20 | 0.42 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | CCR5 | P51681 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 2/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18644664 | 0.95 | JAK2 (0.49) | HTR6JAK2JAK1HPGDSHCAR1 | |
| SCHEMBL18289976 | 0.92 | HTR6 (0.40) | HTR6JAK2JAK1HPGDSHCAR1 | |
| SCHEMBL30111801 | 0.92 | HTR6 (0.40) | HTR6JAK2JAK1HPGDSHCAR1 | |
| SCHEMBL15171260 | 0.89 | HTR6 (0.46) | HTR6JAK2JAK1HPGDSHCAR1 | |
| SCHEMBL16341186 | 0.89 | HTR6 (0.46) | HTR6JAK2JAK1HPGDSHCAR1 | |
| SCHEMBL18645205 | 0.86 | HTR6 (0.55) | HTR6JAK2JAK1HPGDSPRMT5 | |
| SCHEMBL15171143 | 0.84 | JAK2 (0.49) | HTR6JAK2JAK1HPGDSBTK | |
| SCHEMBL15711178 | 0.84 | JAK2 (0.49) | HTR6JAK2JAK1HPGDSBTK | |
| SCHEMBL18285527 | 0.83 | OPRM1 (0.40) | BTKBCHEACHE | |
| SCHEMBL23450731 | 0.82 | BTK (0.46) | HTR6JAK2JAK1HPGDSHCAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017041536-A1 | OXO-DIHYDROIMIDAZO PYRIDINE COMPOUND AND APPLICATIONS THEREOF | 东莞市真兴贝特医药技术有限公司 | 2017-03-16 | — | — | WO | disclosed |