Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 2/20 | 0.57 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.48 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18646519 | 0.90 | NAAA (0.67) | NAAACSNK2A1L3MBTL1CDK1HTT | |
| SCHEMBL18645728 | 0.89 | NAAA (0.74) | NAAAL3MBTL1CDK1HTTSMN1; SMN2 | |
| SCHEMBL8980647 | 0.87 | KDM4E (0.58) | NAAACSNK2A1POLBGRM5P2RX1 | |
| SCHEMBL13753913 | 0.86 | CSNK2A1 (0.56) | NAAACSNK2A1POLBGRM5P2RX1 | |
| SCHEMBL24454271 | 0.85 | CSNK2A1 (0.51) | NAAACSNK2A1POLBGRM5P2RX1 | |
| SCHEMBL12855992 | 0.84 | CSNK2A1 (0.54) | NAAACSNK2A1POLBTDP1GRM5 | |
| SCHEMBL9363837 | 0.82 | ALOX5 (0.58) | NAAAPOLBTHRBRECQLTDP1 | |
| SCHEMBL13634359 | 0.82 | POLB (0.49) | POLBTHRBRECQLTDP1L3MBTL1 | |
| SCHEMBL12121132 | 0.82 | POLB (0.53) | POLBTHRBRECQLTDP1L3MBTL1 | |
| SCHEMBL28456551 | 0.82 | L3MBTL1 (0.49) | POLBTHRBRECQLTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10980755-B2 | LRH-1 modulators | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-04-20 | — | — | US | disclosed |
| WO-2017044889-A1 | LRH-1 MODULATORS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10980755-B2 | LRH-1 modulators | NR1H4, NR1H2, NR1H3 | NAAA 3812/4885CSNK2A1 1861/4885POLB 4347/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.