Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 2/20 | 0.41 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654429 | 0.88 | EPHB3 (0.39) | EPHB3CSNK1DCSNK1EKMT2ANPC1 | |
| SCHEMBL18654723 | 0.86 | EPHB3 (0.40) | EPHB3CSNK1DCSNK1EKMT2ANPC1 | |
| SCHEMBL18654657 | 0.82 | KDM4E (0.40) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL18655239 | 0.80 | CSNK1D (0.38) | EPHB3CSNK1DCSNK1EMAPTALDH1A1 | |
| SCHEMBL14896947 | 0.79 | EPHB3 (0.40) | EPHB3CSNK1DCSNK1EKMT2ANPC1 | |
| SCHEMBL18654739 | 0.79 | POLB (0.35) | EPHB3CSNK1DCSNK1EMAPTALDH1A1 | |
| SCHEMBL14896803 | 0.79 | EPHB3 (0.41) | EPHB3CSNK1DCSNK1EKMT2ANPC1 | |
| SCHEMBL18654415 | 0.78 | TP53 (0.36) | CSNK1DCSNK1ETP53 | |
| SCHEMBL18655240 | 0.77 | CSNK1D (0.36) | CSNK1DCSNK1ESMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL18655200 | 0.77 | MAPT (0.37) | EPHB3CSNK1DCSNK1EKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |