Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.37 |
| ▸ | FYN | P06241 | 2/20 | 0.34 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.33 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654739 | 0.91 | POLB (0.35) | MAPTFYNEPHB3CSNK1DCSNK1E | |
| SCHEMBL18655240 | 0.89 | CSNK1D (0.36) | MAPTFYNCSNK1DCSNK1EPOLB | |
| SCHEMBL18654429 | 0.89 | EPHB3 (0.39) | MAPTFYNEPHB3CSNK1DCSNK1E | |
| SCHEMBL18654743 | 0.87 | MAPT (0.36) | MAPTFYNCSNK1DCSNK1EALDH1A1 | |
| SCHEMBL18654740 | 0.85 | RIPK1 (0.40) | MAPTFYNPOLBTP53KDM4E | |
| SCHEMBL18654658 | 0.84 | EPHB3 (0.35) | MAPTEPHB3CSNK1DCSNK1EPOLB | |
| SCHEMBL18654797 | 0.83 | MAPT (0.37) | MAPTPOLBALDH1A1TP53KDM4E | |
| SCHEMBL18654777 | 0.83 | FYN (0.39) | MAPTFYNPOLBALDH1A1TP53 | |
| SCHEMBL18654802 | 0.82 | ADORA2A (0.36) | MAPTCSNK1DCSNK1EALDH1A1TP53 | |
| SCHEMBL18654986 | 0.81 | MAPT (0.43) | MAPTFYNPOLBALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |