Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHB3 | P54753 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.34 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654739 | 0.91 | POLB (0.35) | EPHB3MAPTPOLBALDH1A1CSNK1D | |
| SCHEMBL18655240 | 0.89 | CSNK1D (0.36) | MAPTTHRBPOLBALDH1A1CSNK1D | |
| SCHEMBL18655200 | 0.89 | MAPT (0.37) | EPHB3MAPTPOLBALDH1A1CSNK1D | |
| SCHEMBL18654428 | 0.88 | EPHB3 (0.41) | EPHB3MAPTTHRBALDH1A1CSNK1D | |
| SCHEMBL18654743 | 0.87 | MAPT (0.36) | MAPTALDH1A1CSNK1DCSNK1ESMN1; SMN2 | |
| SCHEMBL18654740 | 0.85 | RIPK1 (0.40) | MAPTPOLBTP53FYN | |
| SCHEMBL18654723 | 0.84 | EPHB3 (0.40) | EPHB3MAPTTHRBGAAALDH1A1 | |
| SCHEMBL18654777 | 0.83 | FYN (0.39) | MAPTPOLBGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL18654797 | 0.81 | MAPT (0.37) | MAPTPOLBALDH1A1KMT2ARAB9A | |
| SCHEMBL18654986 | 0.81 | MAPT (0.43) | MAPTTHRBPOLBALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |