Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 7/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 7/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | EPHB3 | P54753 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18655240 | 0.89 | CSNK1D (0.36) | CSNK1DCSNK1EADORA3ADORA2AADORA2B | |
| SCHEMBL18654415 | 0.88 | TP53 (0.36) | CSNK1DCSNK1E | |
| SCHEMBL18654626 | 0.87 | CSNK1D (0.37) | CSNK1DCSNK1ETGFBR1ADORA3ADORA2A | |
| SCHEMBL18654802 | 0.87 | ADORA2A (0.36) | CSNK1DCSNK1EADORA3ADORA2AADORA2B | |
| SCHEMBL18654742 | 0.86 | RIPK1 (0.40) | CSNK1DCSNK1E | |
| SCHEMBL18654782 | 0.82 | KDM4E (0.41) | ADORA2AALDH1A1MAPT | |
| SCHEMBL18654428 | 0.80 | EPHB3 (0.41) | CSNK1DCSNK1ETGFBR1ALDH1A1MAPT | |
| SCHEMBL18654739 | 0.79 | POLB (0.35) | CSNK1DCSNK1ETGFBR1USP2ALDH1A1 | |
| SCHEMBL14897228 | 0.79 | NPC1 (0.40) | CSNK1DCSNK1ETGFBR1ADORA3ADORA2A | |
| SCHEMBL18654724 | 0.78 | F11 (0.42) | ADORA2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |