Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 5/20 | 0.36 |
| ▸ | CSNK1E | P49674 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | FYN | P06241 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654739 | 0.91 | POLB (0.35) | CSNK1DCSNK1EKDM4EPOLBFYN | |
| SCHEMBL18654802 | 0.91 | ADORA2A (0.36) | CSNK1DCSNK1EKDM4EADORA3ADORA2A | |
| SCHEMBL18654429 | 0.89 | EPHB3 (0.39) | CSNK1DCSNK1EPOLBSMN1; SMN2FYN | |
| SCHEMBL18655200 | 0.89 | MAPT (0.37) | CSNK1DCSNK1EKDM4EPOLBSMN1; SMN2 | |
| SCHEMBL18655239 | 0.89 | CSNK1D (0.38) | CSNK1DCSNK1EADORA3ADORA2AADORA2B | |
| SCHEMBL18654743 | 0.89 | MAPT (0.36) | CSNK1DCSNK1EKDM4ESMN1; SMN2FYN | |
| SCHEMBL18654740 | 0.87 | RIPK1 (0.40) | KDM4EGLAPOLBFYNMAPT | |
| SCHEMBL18654986 | 0.85 | MAPT (0.43) | KDM4EPOLBSMN1; SMN2FYNALDH1A1 | |
| SCHEMBL18654626 | 0.84 | CSNK1D (0.37) | CSNK1DCSNK1EGLAADORA3ADORA2A | |
| SCHEMBL18654777 | 0.83 | FYN (0.39) | KDM4EPOLBADORA2ASMN1; SMN2FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |