Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 6/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 6/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18654723 | 0.89 | EPHB3 (0.40) | CSNK1DCSNK1ETHRBTGFBR1LMNA | |
| SCHEMBL18654658 | 0.89 | EPHB3 (0.35) | CSNK1DCSNK1ETGFBR1LMNAGLA | |
| SCHEMBL18654323 | 0.88 | NTRK1 (0.35) | CSNK1DCSNK1E | |
| SCHEMBL18655239 | 0.87 | CSNK1D (0.38) | CSNK1DCSNK1EMAP4K1TGFBR1USP2 | |
| SCHEMBL18654863 | 0.86 | RIPK1 (0.37) | CSNK1DCSNK1E | |
| SCHEMBL18655240 | 0.84 | CSNK1D (0.36) | CSNK1DCSNK1ETHRBGLAUSP2 | |
| SCHEMBL18654802 | 0.81 | ADORA2A (0.36) | CSNK1DCSNK1ETHRBUSP2ALDH1A1 | |
| SCHEMBL14897228 | 0.78 | NPC1 (0.40) | CSNK1DCSNK1ETGFBR1USP2ALDH1A1 | |
| SCHEMBL14896802 | 0.76 | NPC1 (0.39) | CSNK1DCSNK1ETGFBR1USP2ALDH1A1 | |
| SCHEMBL18654415 | 0.75 | TP53 (0.36) | CSNK1DCSNK1E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2768509-B1 | SUBSTITUTED BICYCLIC AZA-HETEROCYCLES AND ANALOGUES AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC (US) | 2017-03-22 | — | — | EP | disclosed |