Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTC | P00480 | 1/20 | 0.59 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.50 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 2/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | GRM8 | O00222 | 1/20 | 0.42 |
| ▸ | GRM6 | O15303 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9922798 | 0.95 | OTC (0.54) | OTCNOD1DDAH1GSRHDAC3 | |
| SCHEMBL18643429 | 0.95 | OTC (0.54) | OTCNOD1DDAH1GSRHDAC3 | |
| SCHEMBL12801715 | 0.95 | OTC (0.54) | OTCNOD1DDAH1GSRHDAC3 | |
| SCHEMBL4480340 | 0.87 | OTC (0.53) | OTCNOD1DDAH1GSRHDAC3 | |
| SCHEMBL19733064 | 0.87 | OTC (0.53) | OTCNOD1DDAH1GSRHDAC3 | |
| SCHEMBL2236944 | 0.84 | OTC (0.61) | OTCNOD1DDAH1GSRGRM8 | |
| SCHEMBL2236948 | 0.84 | OTC (0.61) | OTCNOD1DDAH1GSRGRM8 | |
| SCHEMBL16860728 | 0.83 | NOD1 (0.60) | OTCNOD1DDAH1GSR | |
| SCHEMBL18229133 | 0.83 | OTC (0.59) | OTCNOD1DDAH1GSRGRM8 | |
| SCHEMBL16860748 | 0.83 | NOD1 (0.60) | OTCNOD1DDAH1GSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170080006-A1 | METHODS AND COMPOSITIONS FOR REVERSING DISRUPTION OF THE GLYCOCALYX, INFLAMMATION, AND OXIDATIVE DAMAGE | KARDIATONOS, INC. (US) | 2017-03-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170080006-A1 | METHODS AND COMPOSITIONS FOR REVERSING DISRUPTION OF THE GLYCOCALYX, INFLAMMATION, AND OXIDATIVE DAMAGE | MPO, VCAM1, NOX4 | OTC 520/4885NOD1 188/4885DDAH1 3233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.