Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19786040 | 0.86 | KDM4E (0.46) | ALDH1A1CYP2D6L3MBTL1MEN1KMT2A | |
| SCHEMBL18658604 | 0.85 | ALDH1A1 (0.46) | ALDH1A1CYP2D6L3MBTL1GAALMNA | |
| SCHEMBL29133046 | 0.84 | MEN1 (0.50) | ALDH1A1CYP2D6L3MBTL1MEN1KMT2A | |
| SCHEMBL30643025 | 0.84 | MEN1 (0.50) | ALDH1A1CYP2D6L3MBTL1MEN1KMT2A | |
| SCHEMBL17182246 | 0.84 | MLNR (0.41) | ALDH1A1LMNAMAPT | |
| SCHEMBL15783846 | 0.84 | MLNR (0.41) | ALDH1A1LMNAMAPT | |
| SCHEMBL18658781 | 0.76 | RORC (0.55) | L3MBTL1KMT2AMAPTKCNH2 | |
| SCHEMBL18658592 | 0.74 | ALDH1A1 (0.64) | ALDH1A1CYP2D6L3MBTL1MEN1KMT2A | |
| SCHEMBL28356119 | 0.74 | KCNH2 (0.41) | ALDH1A1CYP2D6L3MBTL1GAAMAPT | |
| SCHEMBL28046993 | 0.74 | KCNH2 (0.49) | ALDH1A1LMNAMAPTKDM4EKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3148987-B1 | PIPERAZINE DERIVATIVES AS ROR-GAMMA MODULATORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2019-01-02 | — | — | EP | disclosed |
| EP-3219711-A1 | MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR-GAMMA) FOR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | Glaxo Group Limited (GB) | 2017-09-20 | — | — | EP | disclosed |
| EP-2928885-B1 | MODULATORS OF THE RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR-GAMMA) FOR USE IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2017-03-22 | — | — | EP | disclosed |