SCHEMBL1868577

SCHEMBL1868577

Sc1cccc2c1Nc1ccccc1S2

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOX1 Q9Y5S8 10/20 0.59
MAPT P10636 8/20 0.59
GAA P10253 7/20 0.59
MEN1 O00255 4/20 0.59
KMT2A Q03164 4/20 0.59
ALOX15 P16050 3/20 0.59
SNCA P37840 3/20 0.59
BCHE P06276 2/20 0.59
ACHE P22303 2/20 0.59
TDP1 Q9NUW8 2/20 0.59
CYP1A2 P05177 2/20 0.59
POLB P06746 1/20 0.59
CYP3A4 P08684 1/20 0.59
ADORA3 P0DMS8 1/20 0.59
ALOX12 P18054 1/20 0.59
MAOA P21397 1/20 0.59
CNR1 P21554 1/20 0.59
PTGS1 P23219 1/20 0.59
SLC6A2 P23975 1/20 0.59
HTR2C P28335 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30274184 0.82 NOX1 (0.67) NOX1MAPTGAAMEN1KMT2A
SCHEMBL10530491 0.82 NOX1 (0.67) NOX1MAPTGAAMEN1KMT2A
SCHEMBL31331504 0.78 NOX1 (0.61) NOX1MAPTGAAMEN1KMT2A
SCHEMBL194062 0.78 NOX1 (0.61) NOX1MAPTGAAMEN1KMT2A
SCHEMBL1868575 0.77 NOX1 (0.59) NOX1MAPTGAAMEN1KMT2A
SCHEMBL88106 0.77 NOX1 (0.59) NOX1MAPTGAAMEN1KMT2A
SCHEMBL560873 0.77 NOX1 (0.59) NOX1MAPTGAAMEN1KMT2A
SCHEMBL290846 0.77 NOX1 (0.59) NOX1MAPTGAAMEN1KMT2A
SCHEMBL4534080 0.77 NOX1 (0.59) NOX1MAPTGAAMEN1KMT2A
SCHEMBL344333 0.77 NOX1 (0.59) NOX1MAPTGAAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230089247-A1 NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA ZYDUS LIFESCIENCES LIMITED (IN) 2023-03-23 US disclosed
CN-114901640-A Novel compounds useful for the treatment of dyslipidemia 兹杜斯生命科学有限公司 2022-08-12 CN disclosed
US-20220204453-A1 HETEROCYCLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING HETEROCYCLIC COMPOUND, AND ELECTRONIC APPARATUS INCLUDING ORGANIC LIGHT-EMITTING DEVICE SAMSUNG ELECTRONICS CO., LTD. (KR) 2022-06-30 US disclosed
EP-4019520-A1 HETEROCYCLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING HETEROCYCLIC COMPOUND, AND ELECTRONIC APPARATUS INCLUDING ORGANIC LIGHT-EMITTING DEVICE Samsung Electronics Co., Ltd. (KR) 2022-06-29 EP disclosed
CN-114671873-A Heterocyclic compound, organic light-emitting device including heterocyclic compound, and electronic apparatus including organic light-emitting device 三星电子株式会社 2022-06-28 CN disclosed
WO-2022130352-A1 NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA CADILA HEALTHCARE LIMITED (IN) 2022-06-23 WO disclosed
WO-2021130723-A1 NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA CADILA HEALTHCARE LIMITED (IN) 2021-07-01 WO disclosed
EP-3083587-B1 OXIMINO DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA CADILA HEALTHCARE LTD (IN) 2018-04-04 EP disclosed
EP-3083587-A1 OXIMINO DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA Cadila Healthcare Limited (IN) 2016-10-26 EP disclosed
US-20160083380-A1 OXIMINO DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA CADILA HEALTHCARE LIMITED (IN) 2016-03-24 US disclosed
EP-1930339-A2 Imide compound MITSUI CHEMICALS, INC. (JP) 2008-06-11 EP disclosed
EP-1390664-A4 MATERIALS, METHODS, AND USES FOR PHOTOCHEMICAL GENERATION OF ACIDS AND/OR RADICAL SPECIES UNIV ARIZONA (US) 2008-01-02 EP disclosed
US-20070259151-A1 Imide compound and optical recording media made by using the same MITSUI CHEMICALS, INC. (JP) 2007-11-08 US disclosed
US-7259260-B2 Imide compound and optical recording media made by using the same MITSUI CHEMICALS, INC. (JP) 2007-08-21 US disclosed
US-7217723-B2 Substituted benzothiophenes, e.g., 7Z)-7-hydroxyimino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-sulfonic acid [2-(4-fluorophenyl)-2-hydroxyethyl]-methyl-amide; treating allergies such as atopic dermatitis, allergic coryza, bronchial asthma, hypersensitive pneumoniac and pulmonary aspergillosis. EISAI CO., LTD. (JP) 2007-05-15 US disclosed
US-20050227959-A1 Heterocyclic compound having oxime group EISAI CO., LTD. (JP) 2005-10-13 US disclosed
US-20050208425-A1 Imide compound and optical recording media made by using the same YAMAMOTO CHEMICALS, INC. (JP) 2005-09-22 US disclosed
EP-1445115-A1 IMIDE COMPOUNDS AND OPTICAL RECORDING MEDIA MADE BY USING THE SAME Mitsui Chemicals, Inc. (JP) 2004-08-11 EP disclosed
EP-1390664-A1 MATERIALS, METHODS, AND USES FOR PHOTOCHEMICAL GENERATION OF ACIDS AND/OR RADICAL SPECIES The Arizona Board of Regents (US) 2004-02-25 EP disclosed
WO-2002079691-A1 MATERIALS, METHODS, AND USES FOR PHOTOCHEMICAL GENERATION OF ACIDS AND/OR RADICAL SPECIES THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) 2002-10-10 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230089247-A1 NOVEL COMPOUNDS SUITABLE FOR THE TREATMENT OF DYSLIPIDEMIA PCSK9, CETP, LCAT NOX1 2118/4885MAPT 229/4885GAA 247/4885
US-20220204453-A1 HETEROCYCLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING HETEROCYCLIC COMPOUND, AND ELECTRONIC APPARATUS INCLUDING ORGANIC LIGHT-EMITTING DEVICE CYP1A1, CYP2E1, CYP1A2 NOX1 66/4885MAPT 2428/4885GAA 1912/4885
US-20050208425-A1 Imide compound and optical recording media made by using the same CRY1, MTNR1A, TRPA1 NOX1 291/4885MAPT 2420/4885GAA 4696/4885
US-20050227959-A1 Heterocyclic compound having oxime group STAT6, HRH4, HRH2 NOX1 54/4885MAPT 4554/4885GAA 1738/4885
US-20160083380-A1 OXIMINO DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA OAT, CYP11B2, CYP11B1 NOX1 242/4885MAPT 752/4885GAA 597/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.