Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | OGFRL1 | Q5TC84 | 7/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18691774 | 0.90 | ELANE (0.47) | ELANEADORA3OGFRL1OPRM1OPRK1 | |
| SCHEMBL2783058 | 0.83 | OGFRL1 (0.56) | ADORA3OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL18691758 | 0.81 | HDAC6 (0.42) | OGFRL1OPRM1OPRK1OPRD1KDM4E | |
| SCHEMBL18691789 | 0.80 | TP53 (0.39) | OGFRL1OPRM1OPRK1OPRD1KDM4E | |
| SCHEMBL3346273 | 0.79 | MAPT (0.49) | ELANEADORA3OGFRL1OPRM1OPRK1 | |
| SCHEMBL15147594 | 0.79 | TARBP2 (0.48) | ADORA3OGFRL1OPRM1OPRK1OPRD1 | |
| SCHEMBL15147620 | 0.75 | OGFRL1 (0.44) | ELANEADORA3OGFRL1OPRM1OPRK1 | |
| SCHEMBL18691786 | 0.74 | LMNA (0.60) | CSF1RKDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL18691772 | 0.74 | ADORA3 (0.49) | ELANEADORA3KDM4ERXFP1ALDH1A1 | |
| SCHEMBL18691767 | 0.74 | ALDH1A1 (0.53) | KDM4EALDH1A1GABRA5TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247292-B1 | PYRIDOPYRAZINONES DERIVATIVES INSULIN SECRETION STIMULATORS, METHODS FOR OBTAINING THEM AND USE THEREOF FOR THE TREATMENT OF DIABETES | MERCK PATENT GMBH (DE) | 2017-04-12 | — | — | EP | disclosed |