Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18695267 | 0.83 | ALDH1A1 (0.35) | — | |
| SCHEMBL18735218 | 0.79 | — | — | |
| SCHEMBL24035668 | 0.79 | DGAT1 (0.36) | — | |
| SCHEMBL31328867 | 0.77 | ALDH1A1 (0.31) | — | |
| SCHEMBL18695225 | 0.76 | — | — | |
| SCHEMBL18695205 | 0.76 | TP53 (0.41) | — | |
| SCHEMBL31714301 | 0.74 | CMA1 (0.43) | — | |
| SCHEMBL31328885 | 0.73 | PKM (0.33) | — | |
| SCHEMBL25941733 | 0.73 | POLB (0.31) | — | |
| SCHEMBL16051192 | 0.68 | PTGS2 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3617203-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2020-03-04 | — | — | EP | disclosed |
| EP-3617203-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2020-03-04 | — | — | EP | disclosed |
| US-10106530-B2 | Pyrazolyl substituted tetrahydropyranylsulfones | Grünenthal GmbH (DE) | 2018-10-23 | — | — | US | disclosed |
| US-10100041-B2 | Pyrazolyl substituted tetrahydropyranylsulfones | Grünenthal GmbH (DE) | 2018-10-16 | — | — | US | disclosed |
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
| US-20170101397-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
| US-20170101397-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
| US-20170101397-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | US | disclosed |
| WO-2017059966-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | WO | disclosed |
| WO-2017059965-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | Grünenthal GmbH (DE) | 2017-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170101398-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | TRPV1, CACNA1G, CACNA1B | PRKDC 2965/4885 |
| US-20170101397-A1 | PYRAZOLYL SUBSTITUTED TETRAHYDROPYRANYLSULFONES | TRPV1, CACNA1G, CACNA1B | PRKDC 2965/4885 |
| US-10100041-B2 | Pyrazolyl substituted tetrahydropyranylsulfones | TRPV1, CACNA1G, CACNA1B | PRKDC 2965/4885 |
| US-10106530-B2 | Pyrazolyl substituted tetrahydropyranylsulfones | TRPV1, CACNA1G, CACNA1B | PRKDC 2965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.