Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.38 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 3/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2169939 | 0.78 | FDFT1 (0.40) | HDAC1HDAC6HDAC8ARBACE1 | |
| SCHEMBL12697198 | 0.77 | RRM2 (0.46) | HDAC1HDAC6HDAC8SLC22A12HDAC5 | |
| SCHEMBL12788678 | 0.76 | SLC22A12 (0.41) | HDAC1HDAC6HDAC8SLC22A12HDAC5 | |
| SCHEMBL3632606 | 0.76 | ADRA2A (0.50) | HDAC1HDAC6HDAC8SLC22A12KCNQ3 | |
| SCHEMBL19777764 | 0.76 | CHRNB2 (0.36) | GAANPC1ALDH1A1RAB9ASMN1; SMN2 | |
| SCHEMBL20037762 | 0.76 | MAPT (0.43) | HDAC1HDAC6HDAC8SLC22A12HDAC5 | |
| SCHEMBL9347587 | 0.76 | NPSR1 (0.40) | HDAC1HDAC6HDAC8SLC22A12HDAC5 | |
| SCHEMBL25650053 | 0.76 | STK17A (0.42) | HDAC1HDAC6HDAC8SLC22A12HDAC5 | |
| SCHEMBL22278995 | 0.75 | NPSR1 (0.38) | HDAC1HDAC6HDAC8SLC22A12HDAC5 | |
| SCHEMBL14197601 | 0.74 | RRM2 (0.48) | HDAC1HDAC6HDAC8KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3150599-A1 | NOVEL TETRAHYDROPYRIDOPYRIMIDINE COMPOUND OR SALT THEREOF | Taiho Pharmaceutical Co., Ltd. (JP) | 2017-04-05 | — | — | EP | disclosed |