Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamidoxime SCHEMBL18700865 | 1.00 | RAB9A (0.41) | RAB9ANPC1BRAFMEN1KMT2A | |
| Pyrazole SCHEMBL28833074 | 0.82 | ALDH1A1 (0.44) | RAB9ANPC1KMT2AGAAPOLB | |
| Benzamidoxime SCHEMBL872652 | 0.79 | KMT2A (0.58) | RAB9ANPC1MEN1KMT2AKDM1A | |
| SCHEMBL22872296 | 0.79 | KMT2A (0.58) | RAB9ANPC1MEN1KMT2AKDM1A | |
| Benzamidoxime SCHEMBL30242 | 0.79 | KMT2A (0.58) | RAB9ANPC1MEN1KMT2AKDM1A | |
| Benzamidoxime SCHEMBL102483 | 0.79 | KMT2A (0.58) | RAB9ANPC1MEN1KMT2AKDM1A | |
| Benzamide SCHEMBL29283553 | 0.79 | POLB (0.59) | RAB9ANPC1MEN1KMT2APOLB | |
| Benzamidine SCHEMBL29135567 | 0.79 | F2 (0.59) | KMT2APKM | |
| Benzamide SCHEMBL5106831 | 0.79 | POLB (0.59) | RAB9ANPC1MEN1KMT2APOLB | |
| Benzamide SCHEMBL29078248 | 0.77 | POLB (0.57) | RAB9ANPC1MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10351530-B2 | Arylcyclohexyl pyrazoles as NRF2 regulators | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2019-07-16 | — | — | US | disclosed |
| US-20180282283-A1 | ARYLCYCLOHEXYL PYRAZOLES AS NRF2 REGULATORS | ASTEX THERAPEUTICS LIMITED (GB) | 2018-10-04 | — | — | US | disclosed |
| EP-3371167-A1 | ARYLCYCLOHEXYL PYRAZOLES AS NRF2 REGULATORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2018-09-12 | — | — | EP | disclosed |
| WO-2017060855-A1 | ARYLCYCLOHEXYL PYRAZOLES AS NRF2 REGULATORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2017-04-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180282283-A1 | ARYLCYCLOHEXYL PYRAZOLES AS NRF2 REGULATORS | NFE2L2, KEAP1, NQO1 | RAB9A 2980/4885NPC1 576/4885BRAF 2035/4885 |
| US-10351530-B2 | Arylcyclohexyl pyrazoles as NRF2 regulators | NFE2L2, KEAP1, NQO1 | RAB9A 2980/4885NPC1 576/4885BRAF 2035/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.