Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | SPR | P35270 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RBP4 | P02753 | 4/20 | 0.42 |
| ▸ | RPLP1 | P05386 | 1/20 | 0.42 |
| ▸ | RPLP0 | P05388 | 1/20 | 0.42 |
| ▸ | RPS17 | P08708 | 1/20 | 0.42 |
| ▸ | RPSA | P08865 | 1/20 | 0.42 |
| ▸ | RPS2 | P15880 | 1/20 | 0.42 |
| ▸ | RPL35A | P18077 | 1/20 | 0.42 |
| ▸ | RPL7 | P18124 | 1/20 | 0.42 |
| ▸ | RPL17 | P18621 | 1/20 | 0.42 |
| ▸ | RPS4Y1 | P22090 | 1/20 | 0.42 |
| ▸ | RPS3 | P23396 | 1/20 | 0.42 |
| ▸ | RPS12 | P25398 | 1/20 | 0.42 |
| ▸ | RPL13 | P26373 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3319484 | 0.85 | KDM4E (0.48) | SPR | |
| SCHEMBL18702246 | 0.84 | HSD11B1 (0.47) | CYP3A4SPRHSD11B1KCNH2CYP2C9 | |
| SCHEMBL20835999 | 0.84 | GPR119 (0.56) | MEN1KMT2A | |
| SCHEMBL23235688 | 0.83 | HCAR2 (0.47) | SPRKCNH2RBP4RPLP1RPLP0 | |
| Acetic Acid SCHEMBL29148501 | 0.81 | GPR119 (0.53) | MEN1KMT2A | |
| SCHEMBL3320639 | 0.80 | PDE10A (0.47) | HSD11B1 | |
| SCHEMBL2457409 | 0.79 | GPR119 (0.51) | — | |
| SCHEMBL3319287 | 0.78 | HCAR2 (0.46) | SPRHSD11B1KCNH2RBP4RPLP1 | |
| SCHEMBL2460605 | 0.74 | HCAR2 (0.48) | CYP2C19HCAR2 | |
| SCHEMBL32162354 | 0.74 | HCAR2 (0.48) | CYP2C19HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9963462-B2 | Sepiapterin reductase inhibitors | MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2018-05-08 | — | — | US | disclosed |
| US-20170096435-A1 | SEPIAPTERIN REDUCTASE INHIBITORS | MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2017-04-06 | — | — | US | disclosed |
| US-20170096435-A1 | SEPIAPTERIN REDUCTASE INHIBITORS | MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. (DE) | 2017-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170096435-A1 | SEPIAPTERIN REDUCTASE INHIBITORS | SPR, QDPR, SRR | CYP3A4 436/4885SPR 1/4885HSD11B1 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.