Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 2/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | IDE | P14735 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1921071 | 0.88 | KDM4E (0.47) | KDM4EMAPTMAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL13019107 | 0.82 | KIF11 (0.53) | KDM4EMAPTSMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL31549971 | 0.82 | KIF11 (0.53) | KDM4EMAPTSMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL18705463 | 0.81 | KDM4E (0.57) | KDM4EMAPTMAPK1SMN1; SMN2HSD17B10 | |
| Sr-13668 SCHEMBL29381258 | 0.73 | KDM4E (0.64) | KDM4EMAPTMAPK1SMN1; SMN2HSD17B10 | |
| Sr-13668 SCHEMBL30173443 | 0.73 | KDM4E (0.64) | KDM4EMAPTMAPK1SMN1; SMN2HSD17B10 | |
| Sr-13668 SCHEMBL1071997 | 0.73 | KDM4E (0.64) | KDM4EMAPTMAPK1SMN1; SMN2HSD17B10 | |
| SCHEMBL5494899 | 0.73 | KIF11 (0.62) | KDM4EMAPTSMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL30458204 | 0.73 | KIF11 (0.62) | KDM4EMAPTSMN1; SMN2HSD17B10NPC1 | |
| SCHEMBL23403853 | 0.72 | KDM4E (0.48) | KDM4EMAPTMAPK1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170095450-A1 | Lipoxygenase Inhibitors | SRI INTERNATIONAL | 2017-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170095450-A1 | Lipoxygenase Inhibitors | ALOX15B, ALOX12, ALOX15 | KDM4E 3048/4885MAPT 436/4885MAPK1 3390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.