Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 3/20 | 0.36 |
| ▸ | KRAS | P01116 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.34 |
| ▸ | STS | P08842 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.32 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17866239 | 0.77 | KCNH2 (0.44) | SMN1; SMN2TDP1ERN1TSHRKMT2A | |
| SCHEMBL6696043 | 0.74 | TSHR (0.41) | SMN1; SMN2TDP1ERN1ALOX15TSHR | |
| SCHEMBL1667900 | 0.74 | MAOB (0.46) | TSHRBCHE | |
| SCHEMBL1874194 | 0.73 | ALDH1A1 (0.40) | SMN1; SMN2TDP1ERN1TSHRKMT2A | |
| SCHEMBL10652695 | 0.72 | TSHR (0.47) | ERN1TSHRKMT2AALDH1A1 | |
| SCHEMBL1805361 | 0.72 | GUCY1A1 (0.33) | SMN1; SMN2ERN1KCNH2GUCY1A1GUCY1B1 | |
| SCHEMBL8779748 | 0.70 | TSHR (0.47) | SMN1; SMN2ALOX15TSHRKMT2AALDH1A1 | |
| SCHEMBL2090835 | 0.68 | SIGMAR1 (0.61) | ALOX15TSHRALDH1A1 | |
| SCHEMBL2097665 | 0.68 | MAPT (0.49) | SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL95708 | 0.68 | ERN1 (0.50) | TDP1ERN1KMT2AALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2493905-A1 | BISPHOSPHONATE COMPOUNDS FOR TREATING BONE METABOLISM DISORDERS | Warner Chilcott Company, LLC (PR) | 2012-09-05 | — | — | EP | disclosed |
| WO-2011056589-A1 | BISPHOSPHONATE COMPOUNDS FOR TREATING BONE METABOLISM DISORDERS | WARNER CHILCOTT COMPANY, LLC (US) | 2011-05-12 | — | — | WO | disclosed |