Sugi Predict

Sugi Predict / Compounds / SCHEMBL187207

SCHEMBL187207

SCHEMBL187207

COP(=O)(CC(=O)COc1cccc(C(F)(F)F)c1)OC

nearest known ligand 0.59

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 5/20 0.59
▸ MAOB P27338 2/20 0.48
▸ AOC3 Q16853 1/20 0.48
▸ MRGPRX4 Q96LA9 1/20 0.46
▸ TP53 P04637 1/20 0.45
▸ KMT2A Q03164 2/20 0.45
▸ MEN1 O00255 1/20 0.45
▸ POLB P06746 1/20 0.45
▸ ALDH1A1 P00352 5/20 0.45
▸ GAA P10253 4/20 0.45
▸ LMNA P02545 2/20 0.45
▸ MAPT P10636 2/20 0.45
▸ HTT P42858 1/20 0.45
▸ RXFP1 Q9HBX9 1/20 0.44
▸ SMN1; SMN2 Q16637 2/20 0.43
▸ NR4A2 P43354 1/20 0.43
▸ L3MBTL1 Q9Y468 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11633334 0.90 KDM4E (0.56) KDM4EMAOBAOC3MRGPRX4TP53
SCHEMBL12722064 0.89 KDM4E (0.57) KDM4EMAOBAOC3MRGPRX4TP53
SCHEMBL13641800 0.88 KDM4E (0.63) KDM4EMAOBAOC3MRGPRX4KMT2A
SCHEMBL3149179 0.88 KDM4E (0.47) KDM4EMAOBAOC3MRGPRX4TP53
SCHEMBL5575155 0.85 KDM4E (0.63) KDM4EMAOBAOC3MRGPRX4TP53
SCHEMBL11830641 0.84 ALDH1A1 (0.55) MAOBAOC3ALDH1A1SMN1; SMN2
SCHEMBL9785274 0.83 MRGPRX4 (0.46) KDM4EMAOBMRGPRX4KMT2AMEN1
SCHEMBL11821617 0.82 LMNA (0.60) KDM4ETP53KMT2AMEN1POLB
SCHEMBL5575122 0.82 KDM4E (0.54) KDM4EMAOBAOC3MRGPRX4TP53
SCHEMBL5575128 0.82 KDM4E (0.54) KDM4EMAOBAOC3MRGPRX4TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2013164729-A1 AN IMPROVED AND SCALABLE PROCESS FOR PREPARATION OF PROSTAGLANDIN DERIVATIVES AND INTERMEDIATES THEREOF LUPIN LIMITED (IN) 2013-11-07 — — WO claimed
EP-2802562-B1 PROCESS FOR THE PREPARATION OF TRAVOPROST CHINOIN GYOGYSZER ES VEGYESZETI TERMEKEK GYARA ZRT (HU) 2019-01-23 — — EP disclosed
US-20160137621-A1 PROCESS FOR THE PREPARATION OF TRAVOPROST CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) 2016-05-19 — — US disclosed
US-20160137621-A1 PROCESS FOR THE PREPARATION OF TRAVOPROST CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) 2016-05-19 — — US disclosed
US-9212125-B2 Process for the preparation of travoprost CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) 2015-12-15 — — US disclosed
US-9212125-B2 Process for the preparation of travoprost CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. (HU) 2015-12-15 — — US disclosed
EP-2495235-B1 Process for the synthesis of prostaglandins and intermediates thereof NEWCHEM S P A (IT) 2015-08-05 — — EP disclosed
US-8901319-B2 Process for the preparation of F-series prostaglandins CAYMAN CHEMICAL COMPANY, INCORPORATED (US) 2014-12-02 — — US disclosed
US-8901319-B2 Process for the preparation of F-series prostaglandins CAYMAN CHEMICAL COMPANY, INCORPORATED (US) 2014-12-02 — — US disclosed
US-20140343299-A1 PROCESS FOR THE PREPARATION OF TRAVOPROST EUROAPI HUNGARY LIMITED LIABILITY COMPANY (HU) 2014-11-20 — — US disclosed
WO-2010097672-A1 PROCESS FOR THE PREPARATION OF PROSTAGLANDIN DERIVATIVES SIFAVITOR S.R.L. (IT) 2010-09-02 — — WO disclosed
US-7166730-B2 Process for the preparation of prostaglandin derivatives FINE TECH LABORATORIES, LTD (IL) 2007-01-23 — — US disclosed
US-20050209337-A1 Process for the preparation of prostaglandin derivatives FINETECH LABORATORIES LTD 2005-09-22 — — US disclosed
EP-0342003-B1 USE OF 15-KETOPROSTAGLANDIN E OR F COMPOUNDS FOR UTERINE CONTRACTION Kabushiki Kaisha Ueno Seiyaku Oyo Kenkyujo (JP) 1993-09-08 — — EP disclosed
US-5185374-A Administering to a patient ot interrupt pregnancy K.K. UENO SEIYAKU OYO KENKYUJO (JP) 1993-02-09 — — US disclosed
US-4346228-A Novel 11-oxoprostaglandin derivatives SCHERING AKTIENGESELLSCHAFT (DE) 1982-08-24 — — US disclosed
US-4307112-A 9-Deoxy-9A-methylene isosteres of PGI2 and process for their preparation FARMITALIA CARLO ERBA S.P.A. (IT) 1981-12-22 — — US disclosed
US-4174458-A Novel analogues of prostanoic acids not occurring in nature HOECHST AKTIENGESELLSCHAFT (DE) 1979-11-13 — — US disclosed
US-4098815-A BRONCHODILATOR AGENTS HOECHST AKTIENGESELLSCHAFT (DE) 1978-07-04 — — US disclosed
US-3985791-A 16-Phenoxy and 16-substituted phenoxy-prostatrienoic acid derivatives SYNTEX (U.S.A.) INC. (US) 1976-10-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050209337-A1 Process for the preparation of prostaglandin derivatives PTGIS, PTGES, PTGIR KDM4E 4475/4885MAOB 1250/4885AOC3 2821/4885
US-20160137621-A1 PROCESS FOR THE PREPARATION OF TRAVOPROST PTGIS, PTGIR, TBXA2R KDM4E 4069/4885MAOB 3177/4885AOC3 3036/4885
US-20140343299-A1 PROCESS FOR THE PREPARATION OF TRAVOPROST PTGES, PTGIS, TBXA2R KDM4E 2111/4885MAOB 2483/4885AOC3 3524/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.