Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.49 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11262935 | 0.80 | SIGMAR1 (0.61) | DRD2KCNH2SIGMAR1ABCB1DRD1 | |
| SCHEMBL8672312 | 0.80 | SIGMAR1 (0.79) | SLC6A2SLC6A4SLC6A3DRD2KCNH2 | |
| Hydrochloric Acid SCHEMBL11257115 | 0.79 | SIGMAR1 (0.59) | DRD2KCNH2SIGMAR1ABCB1DRD1 | |
| SCHEMBL5751156 | 0.78 | HRH1 (0.77) | DRD2KCNH2SIGMAR1LTA4HDRD1 | |
| SCHEMBL41969 | 0.77 | SIGMAR1 (0.79) | HTR1ASLC6A4SLC6A3DRD2KCNH2 | |
| SCHEMBL3963041 | 0.77 | SIGMAR1 (0.79) | HTR1ASLC6A4SLC6A3DRD2KCNH2 | |
| Hydrochloric Acid SCHEMBL2195558 | 0.75 | SIGMAR1 (0.77) | HTR1ASLC6A4SLC6A3DRD2KCNH2 | |
| Hydrochloric Acid SCHEMBL16739273 | 0.75 | SIGMAR1 (0.77) | HTR1ASLC6A4SLC6A3DRD2KCNH2 | |
| SCHEMBL29393817 | 0.75 | SIGMAR1 (0.77) | HTR1ASLC6A4SLC6A3DRD2KCNH2 | |
| SCHEMBL4626033 | 0.75 | THRA (0.53) | HTR1ASLC6A2SLC6A4SLC6A3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1870396-B1 | BENZYLOXYPROPYLAMINE DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2012-10-31 | — | — | EP | disclosed |
| US-7939552-B2 | Tachykinin receptor anatgonist; good transfer into blood; long half-life; stability; bradycardial agents; antiinflammatory agents ; antallergens; analgesics; antiemetics; irritable bowel disorders; skin disorders; antidepressants; antiischemic agents ; anxiolytic agents; autoimmune diseases; muscle relax | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2011-05-10 | — | — | US | disclosed |
| US-20080262230-A1 | Benzyloxypropylamine Derivative | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2008-10-23 | — | — | US | disclosed |
| EP-1870396-A1 | BENZYLOXYPROPYLAMINE DERIVATIVE | Nippon Zoki Pharmaceutical Co. Ltd. (JP) | 2007-12-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262230-A1 | Benzyloxypropylamine Derivative | BDKRB2, BDKRB1, PNMT | HTR1A 70/4885SLC6A2 49/4885SLC6A4 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.