Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 6/20 | 0.53 |
| ▸ | THRB | P10828 | 6/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.43 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4647652 | 0.80 | SIGMAR1 (0.46) | THRATHRBSIGMAR1SLC6A4LTA4H | |
| SCHEMBL3963041 | 0.77 | SIGMAR1 (0.79) | SIGMAR1SLC6A4LTA4HSLC6A3HTR1A | |
| SCHEMBL41969 | 0.77 | SIGMAR1 (0.79) | SIGMAR1SLC6A4LTA4HSLC6A3HTR1A | |
| Hydrochloric Acid SCHEMBL2195558 | 0.75 | SIGMAR1 (0.77) | SIGMAR1SLC6A4LTA4HSLC6A3HTR1A | |
| SCHEMBL29393817 | 0.75 | SIGMAR1 (0.77) | SIGMAR1SLC6A4LTA4HSLC6A3HTR1A | |
| Hydrochloric Acid SCHEMBL16739273 | 0.75 | SIGMAR1 (0.77) | SIGMAR1SLC6A4LTA4HSLC6A3HTR1A | |
| SCHEMBL1873419 | 0.75 | HTR1A (0.58) | SIGMAR1SLC6A4HRH3LTA4HSLC6A3 | |
| SCHEMBL22151427 | 0.71 | LTA4H (0.79) | HRH3LTA4HEGFR | |
| SCHEMBL8668531 | 0.71 | SLC6A3 (0.70) | SIGMAR1SLC6A4HRH3SLC6A3HTR1A | |
| SCHEMBL28598401 | 0.70 | GAA (0.65) | THRATHRBESR1NR3C1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1687288-B1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH CORP (US) | 2008-01-16 | — | — | EP | claimed |
| EP-1957473-A2 | PROCESS FOR PREPARING SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES | Wyeth a Corporation of the State of Delaware (US) | 2008-08-20 | — | — | EP | disclosed |
| EP-1687288-B1 | SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES AND METHODS OF THEIR USE | WYETH CORP (US) | 2008-01-16 | — | — | EP | disclosed |
| WO-2007067575-A2 | PROCESS FOR PREPARING SUBSTITUTED ARYL CYCLOALKANOL DERIVATIVES | WYETH (US) | 2007-06-14 | — | — | WO | disclosed |
| US-20070129377-A1 | Process for Preparing Substituted Aryl Cycloalkanol Derivatives | WYETH (US) | 2007-06-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070129377-A1 | Process for Preparing Substituted Aryl Cycloalkanol Derivatives | CYP1A2, CYP3A7, CYP3A43 | THRA 2170/4885THRB 1422/4885SIGMAR1 1046/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.