Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 5/20 | 0.33 |
| ▸ | TDO2 | P48775 | 3/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | MPL | P40238 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA3 | P07451 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.31 |
| ▸ | FEN1 | P39748 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1494448 | 0.74 | MGLL (0.37) | CA12CA1CA2CA4CA6 | |
| SCHEMBL1873870 | 0.70 | IDO1 (0.35) | CASP6IDO1TDO2ADORA2ASCN9A | |
| SCHEMBL1868592 | 0.70 | SCN9A (0.40) | CASP6IDO1TDO2SCN9AMPL | |
| SCHEMBL27928104 | 0.69 | SCN9A (0.41) | CASP6IDO1TDO2SCN9AMPL | |
| SCHEMBL4082911 | 0.66 | MAPK1 (0.41) | CASP6IDO1TDO2ADORA2ASCN9A | |
| SCHEMBL1093963 | 0.66 | IDO1 (0.44) | IDO1TDO2CA12CA1CA2 | |
| SCHEMBL14907942 | 0.65 | DPP4 (0.46) | CASP6IDO1TDO2SCN9AMAPT | |
| SCHEMBL28166233 | 0.65 | IDO1 (0.43) | CASP6IDO1TDO2ADORA2ASCN9A | |
| SCHEMBL21091030 | 0.65 | ADORA2A (0.40) | CASP6IDO1TDO2ADORA2ASCN9A | |
| SCHEMBL15924708 | 0.64 | TAAR1 (0.53) | IDO1CA12CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2498608-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| WO-2011059610-A1 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2011-05-19 | — | — | WO | disclosed |