Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9924089 | 0.71 | CRHBP (0.41) | CRHBPCRHR2ALDH1A1 | |
| SCHEMBL13923529 | 0.71 | CRHBP (0.41) | CRHBPCRHR2ALDH1A1 | |
| SCHEMBL24425747 | 0.71 | CRHBP (0.38) | CRHBPCRHR2 | |
| SCHEMBL25677732 | 0.71 | GRIN2D (0.43) | — | |
| SCHEMBL680047 | 0.69 | CRHBP (0.39) | CRHBPCRHR2ALDH1A1 | |
| SCHEMBL25790737 | 0.69 | CRHBP (0.39) | CRHBPCRHR2ALDH1A1 | |
| SCHEMBL20194007 | 0.69 | CRHBP (0.39) | CRHBPCRHR2ALDH1A1 | |
| SCHEMBL18363105 | 0.69 | CRHBP (0.39) | CRHBPCRHR2ALDH1A1 | |
| SCHEMBL22260668 | 0.69 | CRHBP (0.39) | CRHBPCRHR2ALDH1A1 | |
| SCHEMBL10205004 | 0.67 | CRHBP (0.38) | CRHBPCRHR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10201546-B2 | Quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2019-02-12 | — | — | US | disclosed |
| US-20170182056-A1 | QUINOLINYL MODULATORS OF RORyt | JANSSEN PHARMACEUTICA NV (BE) | 2017-06-29 | — | — | US | disclosed |
| US-9624225-B2 | Quinolinyl modulators of RORγt | JANSSEN PHARMACEUTICA NV (BE) | 2017-04-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10201546-B2 | Quinolinyl modulators of RORγt | RORC, RORB, RORA | CRHBP 2347/4885CRHR2 395/4885ALDH1A1 1190/4885 |
| US-20170182056-A1 | QUINOLINYL MODULATORS OF RORyt | RORC, RORA, RORB | CRHBP 2080/4885CRHR2 651/4885ALDH1A1 1295/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.