Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 18/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 18/20 | 0.37 |
| ▸ | PARP1 | P09874 | 13/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL16703418 | 0.74 | TNKS (0.54) | TNKSTNKS2PARP1 | |
| Trifluoroacetic Acid SCHEMBL16704152 | 0.74 | TNKS (0.54) | TNKSTNKS2PARP1 | |
| SCHEMBL16701424 | 0.68 | TNKS (0.61) | TNKSTNKS2PARP1 | |
| SCHEMBL16701410 | 0.58 | TNKS (0.59) | TNKSTNKS2PARP1 | |
| SCHEMBL5633904 | 0.58 | GABRA1 (0.37) | — | |
| SCHEMBL1035103 | 0.57 | HPGD (0.77) | TNKSTNKS2PARP1 | |
| SCHEMBL18058753 | 0.57 | TNKS (0.65) | TNKSTNKS2PARP1 | |
| Trifluoroacetic Acid SCHEMBL7667563 | 0.57 | HTR3A (0.74) | — | |
| SCHEMBL994468 | 0.56 | ARG1 (0.30) | — | |
| SCHEMBL23854733 | 0.56 | ABHD6 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9624218-B2 | Pyrido[2,3-d]pyrimidin-4-one compounds as tankyrase inhibitors | ELI LILLY AND COMPANY (US) | 2017-04-18 | — | — | US | disclosed |