Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 19/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18759744 | 0.89 | PDK2 (0.52) | PDK2THRBTDP1 | |
| SCHEMBL17050231 | 0.75 | ALDH1A1 (0.45) | PDK2THRBTDP1 | |
| SCHEMBL25134636 | 0.70 | PDK2 (0.44) | PDK2 | |
| SCHEMBL18759751 | 0.70 | THRB (0.50) | PDK2THRBTDP1 | |
| SCHEMBL15691557 | 0.68 | THRB (0.64) | PDK2THRBTDP1 | |
| SCHEMBL13103932 | 0.66 | PDK2 (0.58) | PDK2 | |
| SCHEMBL31211557 | 0.66 | PDK2 (0.54) | PDK2 | |
| SCHEMBL14026066 | 0.66 | ALDH1A1 (0.50) | PDK2THRBTDP1 | |
| SCHEMBL393095 | 0.65 | THRB (0.59) | PDK2THRBTDP1 | |
| SCHEMBL4636505 | 0.65 | THRB (0.48) | PDK2THRBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682060-B2 | Small molecules that induce intrinsic pathway apoptosis | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-06-20 | — | — | US | disclosed |
| US-20170105963-A1 | SMALL MOLECULES THAT INDUCE INTRINSIC PATHWAYS APOPTOSIS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2017-04-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170105963-A1 | SMALL MOLECULES THAT INDUCE INTRINSIC PATHWAYS APOPTOSIS | AIFM1, VDAC1, AFG3L2 | PDK2 1415/4885THRB 3138/4885TDP1 4180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.