Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 5/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15545335 | 0.79 | L3MBTL1 (0.39) | MCHR1KDM4EL3MBTL1HTTNOS1 | |
| SCHEMBL31710095 | 0.75 | BACE1 (0.39) | MCHR1KDM4EHTTNOS1NCF1 | |
| SCHEMBL9810196 | 0.74 | MCHR1 (0.52) | MCHR1KDM4EMAPTL3MBTL1HTT | |
| SCHEMBL964700 | 0.74 | NOS1 (0.39) | MCHR1KDM4EHTTNOS1NCF1 | |
| SCHEMBL15587576 | 0.73 | PAX8 (0.37) | MCHR1KDM4EL3MBTL1HTTNOS1 | |
| SCHEMBL15650884 | 0.72 | NOS1 (0.54) | KDM4EMAPTHTTNOS1NCF1 | |
| SCHEMBL7970266 | 0.72 | MCHR1 (0.50) | MCHR1KDM4EMAPTL3MBTL1NOS1 | |
| SCHEMBL359862 | 0.72 | MCHR1 (0.50) | MCHR1KDM4EMAPTL3MBTL1NOS1 | |
| SCHEMBL3771034 | 0.72 | NOS3 (0.54) | MCHR1KDM4EMAPTL3MBTL1NOS1 | |
| SCHEMBL27699482 | 0.72 | TUBB4A (0.44) | KDM4EMAPTL3MBTL1HTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2870144-B1 | OREXIN RECEPTOR ANTAGONISTS | HEPTARES THERAPEUTICS LTD (GB) | 2017-04-19 | — | — | EP | disclosed |