Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18753306 | 0.87 | GBA1 (0.44) | LMNAGBA1GAACYP3A4CYP1A2 | |
| SCHEMBL18753365 | 0.86 | P2RX7 (0.45) | DPP4DPP9LMNAGAACYP3A4 | |
| SCHEMBL18753305 | 0.86 | L3MBTL1 (0.56) | DPP4DPP9GAAMEN1KMT2A | |
| SCHEMBL18753814 | 0.85 | SMN1; SMN2 (0.48) | LMNAGBA1GAACYP3A4MEN1 | |
| SCHEMBL18753323 | 0.84 | POLB (0.57) | DPP4MEN1KMT2AABL1BCR | |
| SCHEMBL22422416 | 0.84 | DPP4 (0.44) | DPP4DPP9LMNAGBA1GAA | |
| SCHEMBL18753319 | 0.83 | MGLL (0.51) | MEN1KMT2APARP1NAMPT | |
| SCHEMBL18753379 | 0.81 | KMT2A (0.61) | LMNAGAAHSD17B10MEN1KMT2A | |
| SCHEMBL18753448 | 0.77 | LMNA (0.51) | LMNAGAACYP1A2HSD17B10CYP2C9 | |
| SCHEMBL18753373 | 0.76 | ALDH1A1 (0.57) | LMNAHSD17B10MEN1KMT2AABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3241554-A1 | QUINOLINE-8-SULFONAMIDE DERIVATES HAVING AN ANTICANCER ACTIVITY | Agios Pharmaceuticals, Inc. (US) | 2017-11-08 | — | — | EP | disclosed |
| EP-2448582-B1 | QUINOLINE-8-SULFONAMIDE DERIVATIVES HAVING AN ANTICANCER ACTIVITY | AGIOS PHARMACEUTICALS INC (US) | 2017-04-19 | — | — | EP | disclosed |