Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 4/20 | 0.34 |
| ▸ | NOS3 | P29474 | 3/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.31 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | PDXK | O00764 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26849033 | 0.84 | CCR1 (0.32) | NOS2NOS3CCR1CCR5CCR8 | |
| SCHEMBL10426329 | 0.83 | CCR1 (0.37) | NOS2NOS3CCR1CCR5CCR8 | |
| SCHEMBL8432596 | 0.78 | MLYCD (0.36) | — | |
| SCHEMBL8437176 | 0.78 | GRM4 (0.45) | — | |
| SCHEMBL19621113 | 0.75 | PDXK (0.30) | PDXK | |
| SCHEMBL15417589 | 0.74 | CCR1 (0.39) | NOS2NOS3CCR1CCR5CCR8 | |
| SCHEMBL19365338 | 0.72 | — | — | |
| SCHEMBL25627501 | 0.72 | CCR1 (0.38) | NOS2NOS3CCR1CCR5CCR8 | |
| SCHEMBL22239425 | 0.72 | NOS3 (0.42) | NOS2NOS3 | |
| SCHEMBL26219999 | 0.71 | FGF23 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2532657-B9 | Compounds and methods of use | SUNSHINE LAKE PHARMA CO LTD (CN) | 2017-04-19 | — | — | EP | disclosed |