Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | LGALS8 | O00214 | 1/20 | 0.48 |
| ▸ | TGM2 | P21980 | 1/20 | 0.46 |
| ▸ | SYNJ2 | O15056 | 2/20 | 0.45 |
| ▸ | MGMT | P16455 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8985399 | 0.96 | TGM2 (0.49) | HTTMAOBLMNASMN1; SMN2LGALS8 | |
| SCHEMBL28333071 | 0.94 | LMNA (0.54) | HTTMAOBLMNASMN1; SMN2LGALS8 | |
| SCHEMBL12094113 | 0.90 | LGALS3 (0.54) | HTTMAOBLGALS8TGM2 | |
| SCHEMBL19036050 | 0.90 | LGALS3 (0.54) | HTTMAOBLGALS8TGM2 | |
| SCHEMBL12094119 | 0.90 | LGALS3 (0.54) | HTTMAOBLGALS8TGM2 | |
| SCHEMBL30891325 | 0.89 | HTT (0.46) | HTTMAOBLMNASMN1; SMN2LGALS8 | |
| SCHEMBL30391620 | 0.89 | HTT (0.46) | HTTMAOBLMNASMN1; SMN2LGALS8 | |
| SCHEMBL30891388 | 0.89 | TGM2 (0.44) | HTTMAOBLMNASMN1; SMN2LGALS8 | |
| SCHEMBL30891438 | 0.87 | HTT (0.43) | HTTMAOBLMNASMN1; SMN2LGALS8 | |
| SCHEMBL24699869 | 0.87 | MAPK1 (0.57) | LGALS8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10696707-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2020-06-30 | — | — | US | disclosed |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2019-05-09 | — | — | US | disclosed |
| US-10246478-B2 | Polyene macrolide derivative | SHIONOGI & CO., LTD. (JP) | 2019-04-02 | — | — | US | disclosed |
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-07-06 | — | — | US | disclosed |
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-07-06 | — | — | US | disclosed |
| EP-3156410-A1 | POLYENE MACROLIDE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 2017-04-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190729-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | HTT 1050/4885MAOB 645/4885LMNA 742/4885 |
| US-10246478-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | HTT 1050/4885MAOB 645/4885LMNA 742/4885 |
| US-20190135847-A1 | POLYENE MACROLIDE DERIVATIVE | ERG28, RPL23, RPL10 | HTT 1050/4885MAOB 645/4885LMNA 742/4885 |
| US-10696707-B2 | Polyene macrolide derivative | ERG28, RPL23, RPL10 | HTT 1050/4885MAOB 645/4885LMNA 742/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.