Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768441 | 0.93 | USP2 (0.47) | MDM2USP2OPRM1OPRD1OPRK1 | |
| SCHEMBL18768444 | 0.92 | MDM2 (0.50) | MDM2USP2DRD2DRD1DRD4 | |
| SCHEMBL18768632 | 0.90 | ALDH1A1 (0.43) | USP2DRD2DRD1DRD4HTR2C | |
| SCHEMBL18768445 | 0.88 | PDGFRB (0.44) | JAK2JAK1TYK2DRD2DRD3 | |
| SCHEMBL18768577 | 0.88 | DRD2 (0.43) | MDM2USP2DRD2DRD1DRD4 | |
| SCHEMBL18768630 | 0.86 | KDM4E (0.40) | MDM2OPRM1OPRD1 | |
| SCHEMBL18768442 | 0.82 | PKM (0.39) | DRD2DRD4DRD3 | |
| SCHEMBL18768446 | 0.81 | MEN1 (0.45) | DRD2DRD1DRD4HTR2CDRD3 | |
| SCHEMBL18768434 | 0.78 | — | — | |
| SCHEMBL18767437 | 0.78 | MDM2 (0.43) | MDM2DRD2DRD1DRD4HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066705-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES | AQUINNAH PHARMACEUTICALS, INC. (US) | 2017-04-20 | — | — | WO | disclosed |