Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | CXCR6 | O00574 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18768442 | 0.89 | PKM (0.39) | KDM4EALDH1A1AKR1C3MAOB | |
| SCHEMBL18768441 | 0.89 | USP2 (0.47) | MDM2OPRM1OPRD1 | |
| SCHEMBL18768444 | 0.88 | MDM2 (0.50) | MDM2 | |
| SCHEMBL18768446 | 0.88 | MEN1 (0.45) | KDM4EALDH1A1AKR1C3CXCR6 | |
| SCHEMBL18768451 | 0.86 | MDM2 (0.44) | MDM2OPRM1OPRD1 | |
| SCHEMBL18768577 | 0.86 | DRD2 (0.43) | MDM2OPRM1OPRD1 | |
| SCHEMBL18768576 | 0.85 | LMNA (0.47) | — | |
| SCHEMBL18768632 | 0.82 | ALDH1A1 (0.43) | ALDH1A1 | |
| SCHEMBL18768445 | 0.81 | PDGFRB (0.44) | OPRM1OPRD1 | |
| SCHEMBL18768432 | 0.80 | AKR1C3 (0.45) | KDM4EALDH1A1MDM2AKR1C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017066705-A1 | COMPOUNDS, COMPOSITIONS AND METHODS OF USE AGAINST STRESS GRANULES | AQUINNAH PHARMACEUTICALS, INC. (US) | 2017-04-20 | — | — | WO | disclosed |