Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27849202 | 0.86 | ALDH1A1 (0.40) | ALDH1A1SOS1KDM4EGAAMITF | |
| SCHEMBL11333220 | 0.84 | ALDH1A1 (0.41) | ALDH1A1SOS1KDM4EGAAMITF | |
| SCHEMBL27719532 | 0.80 | ALDH1A1 (0.43) | ALDH1A1SOS1KDM4EGAAMITF | |
| SCHEMBL63286 | 0.75 | ALDH1A1 (0.59) | ALDH1A1SOS1KDM4EGAAMITF | |
| SCHEMBL5353581 | 0.75 | MITF (0.46) | ALDH1A1SOS1KDM4EGAAMITF | |
| SCHEMBL10745171 | 0.74 | ALDH1A1 (0.39) | ALDH1A1SOS1KDM4EGAAMITF | |
| SCHEMBL3282371 | 0.73 | ALDH1A1 (0.44) | ALDH1A1SOS1KDM4EGAAMITF | |
| SCHEMBL19674728 | 0.73 | ALDH1A1 (0.44) | ALDH1A1SOS1KDM4EGAAMITF | |
| SCHEMBL8276768 | 0.73 | ALDH1A1 (0.45) | ALDH1A1SOS1KDM4EGAAMITF | |
| SCHEMBL10747309 | 0.73 | TXNRD1 (0.39) | ALDH1A1SOS1KDM4EGAAMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170112891-A1 | HINDERED DISULFIDE DRUG CONJUGATES | GENENTECH INC (US) | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170112891-A1 | HINDERED DISULFIDE DRUG CONJUGATES | STS, TST, SCLY | ALDH1A1 143/4885SOS1 403/4885KDM4E 3411/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.