Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | BCHE | P06276 | 6/20 | 0.41 |
| ▸ | ACHE | P22303 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.41 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.41 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.41 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.41 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20368721 | 0.97 | KDM4E (0.51) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL21963241 | 0.77 | ACHE (0.49) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL18779343 | 0.76 | LDHA (0.44) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL17111546 | 0.73 | P2RX7 (0.41) | ALDH1A1SMN1; SMN2LMNAHTTPLA2G1B | |
| SCHEMBL30657668 | 0.73 | HSD17B10 (0.58) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL7295408 | 0.72 | ACHE (0.52) | KDM4EHSD17B10ALDH1A1BCHEACHE | |
| SCHEMBL22853569 | 0.71 | CYP1A2 (0.47) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL18399566 | 0.71 | ALDH1A1 (0.40) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 | |
| SCHEMBL22018823 | 0.70 | SMN1; SMN2 (0.48) | ALDH1A1SMN1; SMN2HPGDADORA3NFKB1 | |
| SCHEMBL12884366 | 0.70 | KDM4E (0.67) | KDM4EHSD17B10ALDH1A1ADORA2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9815846-B2 | TrkA kinase inhibitors, compositions and methods thereof | MERCK SHARP & DOHME CORP. (US) | 2017-11-14 | — | — | US | disclosed |
| US-20170114071-A1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170114071-A1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | NGFR, NGF, NTRK1 | KDM4E 3594/4885HSD17B10 3700/4885ALDH1A1 4290/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.