SCHEMBL18780

SCHEMBL18780

O=c1nc(-c2nccc(C(F)(F)F)n2)[nH]o1

nearest known ligand 0.36

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
IDH1 O75874 6/20 0.36
ADRB1 P08588 1/20 0.36
IDH2 P48735 4/20 0.36
HDAC4 P56524 3/20 0.35
PIM1 P11309 2/20 0.34
PIM2 Q9P1W9 2/20 0.34
PIM3 Q86V86 1/20 0.34
TAS2R14 Q9NYV8 2/20 0.32
LOXL2 Q9Y4K0 2/20 0.32
HPGD P15428 1/20 0.31
LOX P28300 1/20 0.31
SYK P43405 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18781 0.75 ALDH1A1 (0.38) IDH1ADRB1IDH2HDAC4PIM1
SCHEMBL15102668 0.73 IDH1 (0.36) IDH1ADRB1IDH2HDAC4PIM1
SCHEMBL29763275 0.73 IDH1 (0.36) IDH1ADRB1IDH2HDAC4PIM1
SCHEMBL2338600 0.72 NOS3 (0.40) ADRB1SYK
SCHEMBL2341676 0.71 TRPV1 (0.30)
SCHEMBL18107 0.70 CA2 (0.39) PIM2PIM3HPGD
SCHEMBL17833 0.69 IDH1 (0.36) IDH1ADRB1IDH2HDAC4PIM1
SCHEMBL2340433 0.67 ALDH1A1 (0.36) SYK
SCHEMBL2335005 0.67
SCHEMBL600563 0.67 HPGD (0.34) HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012025460-A1 OXADIAZOLINONE DERIVATIVES AND USE THEREOF IN PEST CONTROL BAYER CROPSCIENCE AG (DE) 2012-03-01 WO disclosed