SCHEMBL18784166

SCHEMBL18784166

CSc1ccc(Cl)nc1C(O)=S

nearest known ligand 0.34

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.34
KMT2A Q03164 1/20 0.34
MAPKAPK2 P49137 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26632269 0.81 KMT2A (0.49) MEN1KMT2AL3MBTL1
SCHEMBL31298313 0.81 KMT2A (0.49) MEN1KMT2AL3MBTL1
SCHEMBL18784156 0.81 ALDH1A1 (0.32) KMT2AL3MBTL1
SCHEMBL18784205 0.78 KMT2A (0.40) KMT2AL3MBTL1
SCHEMBL18784202 0.78 CTH (0.32) L3MBTL1
SCHEMBL18940892 0.76 KDM4E (0.39) MEN1KMT2AL3MBTL1
SCHEMBL28844073 0.76 KMT2A (0.37) MEN1KMT2AL3MBTL1
SCHEMBL18784183 0.76 TLR8 (0.37) MEN1KMT2AL3MBTL1
SCHEMBL18784139 0.74 CRHBP (0.42) MEN1KMT2AL3MBTL1
SCHEMBL31393261 0.74 L3MBTL1 (0.55) MEN1KMT2AL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3162795-B1 METHOD FOR MANUFACTURING 3-(ALKYL SULFONYL)PYRIDINE-2-CARBOXYLIC ACID SUMITOMO CHEMICAL CO (JP) 2019-07-31 EP disclosed
CN-106660958-B The manufacturing method of 3- (alkyl sulphonyl) pyridine-2-carboxylic acids 住友化学株式会社 2019-04-12 CN disclosed
US-9815786-B2 Method for manufacturing 3-(alkylsulfonyl)pyridine-2-carboxylic acid SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-11-14 US disclosed
US-20170129859-A1 METHOD FOR MANUFACTURING 3-(ALKYLSULFONYL)PYRIDINE-2-CARBOXYLIC ACID SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2017-05-11 US disclosed
CN-106660958-A Method for manufacturing 3-(alkyl sulfonyl)pyridine-2-carboxylic acid 住友化学株式会社 2017-05-10 CN disclosed
EP-3162795-A1 METHOD FOR MANUFACTURING 3-(ALKYL SULFONYL)PYRIDINE-2-CARBOXYLIC ACID Sumitomo Chemical Company, Limited (JP) 2017-05-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170129859-A1 METHOD FOR MANUFACTURING 3-(ALKYLSULFONYL)PYRIDINE-2-CARBOXYLIC ACID STS, SRM, CERS2 MEN1 1779/4885KMT2A 502/4885MAPKAPK2 232/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.