Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NAT1 | P18440 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD4 | P21917 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648645 | 0.85 | METAP2 (0.42) | HTR7ALDH1A1KDM4ESMN1; SMN2NAT1 | |
| SCHEMBL18784224 | 0.85 | ALOX5AP (0.37) | ALDH1A1KDM4ESMN1; SMN2NAT1MCL1 | |
| Hydrochloric Acid SCHEMBL1647980 | 0.84 | METAP2 (0.42) | HTR7ALDH1A1KDM4ESMN1; SMN2NAT1 | |
| SCHEMBL1648086 | 0.83 | METAP2 (0.41) | ALDH1A1KDM4ESMN1; SMN2NAT1MCL1 | |
| SCHEMBL18784219 | 0.80 | METAP2 (0.36) | ALDH1A1KDM4ESMN1; SMN2NAT1GBA1 | |
| SCHEMBL18784217 | 0.80 | GBA1 (0.34) | ALDH1A1KDM4ESMN1; SMN2NAT1GBA1 | |
| SCHEMBL1648648 | 0.79 | ALDH1A1 (0.35) | ALDH1A1KDM4ESMN1; SMN2GBA1METAP2 | |
| Hydrochloric Acid SCHEMBL14717753 | 0.79 | ALDH1A1 (0.34) | ALDH1A1KDM4ESMN1; SMN2GBA1METAP2 | |
| SCHEMBL18784246 | 0.78 | HTR7 (0.43) | HTR7ALDH1A1KDM4ESMN1; SMN2GBA1 | |
| SCHEMBL1648904 | 0.76 | PDK2 (0.38) | NAT1MCL1METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-B1 | SULPHONE COMPOUNDS FOR USE IN THE TREATMENT OF OBESITY | ZAFGEN INC (US) | 2017-05-03 | — | — | EP | claimed |