Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14717753 | 0.99 | ALDH1A1 (0.34) | ALDH1A1KDM4ESMN1; SMN2GBA1FABP4 | |
| SCHEMBL18784218 | 0.89 | ALDH1A1 (0.31) | ALDH1A1KDM4ESMN1; SMN2GBA1EGFR | |
| Hydrochloric Acid SCHEMBL1648366 | 0.86 | FABP4 (0.33) | FABP4FABP5POLBCNR2 | |
| SCHEMBL1648645 | 0.83 | METAP2 (0.42) | ALDH1A1KDM4ESMN1; SMN2GBA1FABP4 | |
| Hydrochloric Acid SCHEMBL1647980 | 0.82 | METAP2 (0.42) | ALDH1A1KDM4ESMN1; SMN2GBA1FABP4 | |
| SCHEMBL1649998 | 0.81 | CA1 (0.41) | ALDH1A1FABP4FABP5POLBMETAP2 | |
| SCHEMBL18784248 | 0.79 | HTR7 (0.38) | ALDH1A1KDM4ESMN1; SMN2GBA1NPC1 | |
| SCHEMBL1648086 | 0.79 | METAP2 (0.41) | ALDH1A1KDM4ESMN1; SMN2FABP4FABP5 | |
| SCHEMBL1648984 | 0.77 | MAPT (0.42) | KDM4ESMN1; SMN2FABP4FABP5POLB | |
| SCHEMBL18784219 | 0.76 | METAP2 (0.36) | ALDH1A1KDM4ESMN1; SMN2GBA1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen Corporation (US) | 2012-08-15 | — | — | EP | claimed |
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | claimed |