Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 2/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PI4KA | P42356 | 6/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 6/20 | 0.36 |
| ▸ | PI4K2A | Q9BTU6 | 6/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 2/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17060216 | 0.85 | NUDT1 (0.62) | NUDT1ADORA2AADORA1ERAP1LMNA | |
| SCHEMBL12799133 | 0.80 | NUDT1 (0.41) | NUDT1ADORA2AADORA1LMNAPI4KA | |
| SCHEMBL17574489 | 0.80 | MEN1 (0.43) | NUDT1ADORA2AADORA1LMNATSHR | |
| SCHEMBL5132695 | 0.79 | LMNA (0.48) | NUDT1ADORA2AADORA1LMNATSHR | |
| SCHEMBL13050401 | 0.78 | HSP90AA1 (0.42) | NUDT1ADORA2AADORA1LMNATSHR | |
| SCHEMBL18786151 | 0.77 | KDM4E (0.45) | — | |
| SCHEMBL42313 | 0.77 | ADORA2A (0.42) | NUDT1ADORA2AADORA1ERAP1LMNA | |
| SCHEMBL16487211 | 0.77 | HSP90B1 (0.44) | NUDT1ADORA2AADORA1ERAP1LMNA | |
| SCHEMBL16487138 | 0.77 | LMNA (0.46) | NUDT1LMNATSHRERBB2HSP90AA1 | |
| SCHEMBL16486508 | 0.77 | LMNA (0.49) | LMNATSHRERBB2HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10729738-B2 | Hindered disulfide drug conjugates | GENENTECH, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-20170112891-A1 | HINDERED DISULFIDE DRUG CONJUGATES | GENENTECH INC (US) | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10729738-B2 | Hindered disulfide drug conjugates | STS, TST, SCLY | NUDT1 2606/4885ADORA2A 3821/4885ADORA1 4186/4885 |
| US-20170112891-A1 | HINDERED DISULFIDE DRUG CONJUGATES | STS, TST, SCLY | NUDT1 2606/4885ADORA2A 3821/4885ADORA1 4186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.