Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | DHODH | Q02127 | 15/20 | 0.44 |
| ▸ | PARP1 | P09874 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18786057 | 0.84 | KDM4E (0.59) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL18786153 | 0.77 | NUDT1 (0.43) | — | |
| SCHEMBL7969798 | 0.74 | DHODH (0.58) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL8260543 | 0.72 | KDM4E (0.60) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL30052374 | 0.70 | PARP1 (0.47) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL5132695 | 0.69 | LMNA (0.48) | — | |
| SCHEMBL9725333 | 0.68 | DHODH (0.77) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL8952887 | 0.67 | KDM4E (0.62) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL7863163 | 0.67 | PARP1 (0.63) | KDM4EHPGDDHODHPARP1 | |
| SCHEMBL27720114 | 0.67 | KDM4E (0.57) | KDM4EHPGDDHODHPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10729738-B2 | Hindered disulfide drug conjugates | GENENTECH, INC. (US) | 2020-08-04 | — | — | US | disclosed |
| US-20170112891-A1 | HINDERED DISULFIDE DRUG CONJUGATES | GENENTECH INC (US) | 2017-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10729738-B2 | Hindered disulfide drug conjugates | STS, TST, SCLY | KDM4E 3411/4885HPGD 1025/4885DHODH 215/4885 |
| US-20170112891-A1 | HINDERED DISULFIDE DRUG CONJUGATES | STS, TST, SCLY | KDM4E 3411/4885HPGD 1025/4885DHODH 215/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.