Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | F13A1 | P00488 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | TGM1 | P22735 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23669168 | 1.00 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL5993395 | 1.00 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL12944961 | 1.00 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL23669881 | 1.00 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL15866093 | 1.00 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL14031173 | 0.89 | HPGD (0.42) | NR1H2USP2SMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL22035920 | 0.88 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL21388760 | 0.88 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL18814078 | 0.88 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2NAMPTMEN1 | |
| SCHEMBL22331591 | 0.84 | NR1H2 (0.43) | NR1H2USP2SMN1; SMN2NAMPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250145632-A1 | Pyrimidine Heterocyclic Compound, Preparation Method Thereof and use Thereof in Medicine | INSILICO MEDICINE IP LIMITED (HK) | 2025-05-08 | — | — | US | disclosed |
| EP-4455132-A1 | PYRIMIDINE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | Insilico Medicine IP Limited (HK) | 2024-10-30 | — | — | EP | disclosed |
| US-12091425-B2 | Compounds that inhibit MCL-1 protein | AMGEN INC. (US) | 2024-09-17 | — | — | US | disclosed |
| CN-118647607-A | Pyrimidine heterocyclic compounds, process for preparing the same and pharmaceutical use thereof | 英矽智能科技(上海)有限公司 | 2024-09-13 | — | — | CN | disclosed |
| EP-4011887-B1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | CALITHERA BIOSCIENCES INC (US) | 2024-07-31 | — | — | EP | disclosed |
| WO-2023116761-A1 | PYRIMIDINE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 英矽智能科技知识产权有限公司 | 2023-06-29 | — | — | WO | disclosed |
| WO-2023116761-A1 | PYRIMIDINE HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE | 英矽智能科技知识产权有限公司 | 2023-06-29 | — | — | WO | disclosed |
| US-20230052348-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2023-02-16 | — | — | US | disclosed |
| US-20230052348-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | AMGEN INC. (US) | 2023-02-16 | — | — | US | disclosed |
| US-11370754-B2 | Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide | CALITHERA BIOSCIENCES, INC. (US) | 2022-06-28 | — | — | US | disclosed |
| US-20180362459-A1 | METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE | PRECISION PHARMACEUTICALS, INC. | 2018-12-20 | — | — | US | disclosed |
| US-20180346489-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | PRECISION PHARMACEUTICALS, INC. | 2018-12-06 | — | — | US | disclosed |
| WO-2018209290-A1 | METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE | CALITHERA BIOSCIENCES, INC. (US) | 2018-11-15 | — | — | WO | disclosed |
| EP-3368541-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | Calithera Biosciences, Inc. (US) | 2018-09-05 | — | — | EP | disclosed |
| US-10065974-B2 | Compositions and methods for inhibiting arginase activity | PRECISION PHARMACEUTICALS, INC. | 2018-09-04 | — | — | US | disclosed |
| US-20170121352-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | PRECISION PHARMACEUTICALS, INC. | 2017-05-04 | — | — | US | disclosed |
| US-20170121352-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | PRECISION PHARMACEUTICALS, INC. | 2017-05-04 | — | — | US | disclosed |
| US-20170121352-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | PRECISION PHARMACEUTICALS, INC. | 2017-05-04 | — | — | US | disclosed |
| WO-2017075363-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | CALITHERA BIOSCIENCES, INC. (US) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017075363-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | CALITHERA BIOSCIENCES, INC. (US) | 2017-05-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180362459-A1 | METHOD OF PREPARING (3R,4S)-3-ACETAMIDO-4-ALLYL-N-(TERT-BUTYL)PYRROLIDINE-3-CARBOXAMIDE | TERT, CTPS1, CTPS2 | NR1H2 4072/4885USP2 3667/4885SMN1; SMN2 1991/4885 |
| US-20180346489-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | ARG1, ARG2, PRMT5 | NR1H2 390/4885USP2 954/4885SMN1; SMN2 4691/4885 |
| US-20250145632-A1 | Pyrimidine Heterocyclic Compound, Preparation Method Thereof and use Thereof in Medicine | DPYD, TYMP, NUDT1 | NR1H2 2693/4885USP2 4835/4885SMN1; SMN2 1840/4885 |
| US-20170121352-A1 | COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY | ARG1, ARG2, PRMT5 | NR1H2 390/4885USP2 954/4885SMN1; SMN2 4691/4885 |
| US-11370754-B2 | Method of preparing (3R,4S)-3-acetamido-4-allyl-n-(tert-butyl)pyrrolidine-3-carboxamide | TERT, CTPS1, CTPS2 | NR1H2 4072/4885USP2 3667/4885SMN1; SMN2 1991/4885 |
| US-10065974-B2 | Compositions and methods for inhibiting arginase activity | ARG1, ARG2, PRMT5 | NR1H2 390/4885USP2 954/4885SMN1; SMN2 4691/4885 |
| US-20230052348-A1 | COMPOUNDS THAT INHIBIT MCL-1 PROTEIN | MCL1, BCL9, BCL2L1 | NR1H2 2519/4885USP2 1042/4885SMN1; SMN2 1807/4885 |
| US-12091425-B2 | Compounds that inhibit MCL-1 protein | MCL1, BCL9, BCL2L1 | NR1H2 2519/4885USP2 1042/4885SMN1; SMN2 1807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.