Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 2/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.36 |
| ▸ | C1S | P09871 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 2/20 | 0.34 |
| ▸ | NOS1 | P29475 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18793352 | 0.80 | POLB (0.38) | PRSS1PRSS2PRSS3C1SKDM4E | |
| SCHEMBL14826020 | 0.75 | SLC9A1 (0.33) | SLC9A1IKBKB | |
| SCHEMBL23369540 | 0.75 | PRSS1 (0.32) | PRSS1PRSS2PRSS3C1SPLAU | |
| SCHEMBL14826019 | 0.75 | PRSS1 (0.32) | PRSS1PRSS2PRSS3C1SPLAU | |
| SCHEMBL3220307 | 0.74 | NOS3 (0.48) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL27707436 | 0.69 | NNMT (0.49) | KDM4EALDH1A1GAAGLAHPGD | |
| SCHEMBL18793097 | 0.69 | NOS3 (0.52) | PRSS1PRSS2PRSS3C1SNOS3 | |
| SCHEMBL14827743 | 0.67 | KDM4E (0.36) | PRSS1PRSS2PRSS3KDM4EALDH1A1 | |
| SCHEMBL820013 | 0.67 | PRSS1 (0.40) | PRSS1PRSS2PRSS3C1SPLAU | |
| SCHEMBL27011410 | 0.67 | PRSS1 (0.45) | PRSS1PRSS2PRSS3C1SPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2877176-B1 | DERIVATIVES OF AZAINDAZOLE OR DIAZAINDAZOLE TYPE FOR TREATING A CANCER OVEREXPRESSING TRK | PF MEDICAMENT (FR) | 2017-04-26 | — | — | EP | disclosed |