SCHEMBL820013

SCHEMBL820013

Cc1cc(C(=N)N)c(C)c(C)c1C

nearest known ligand 0.40

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ PRSS1 P07477 2/20 0.40
▸ PRSS2 P07478 2/20 0.40
▸ PRSS3 P35030 2/20 0.40
▸ C1S P09871 1/20 0.39
▸ SLC11A2 P49281 1/20 0.35
▸ MAPT P10636 1/20 0.33
▸ PLAU P00749 1/20 0.32
▸ NQO2 P16083 1/20 0.31
▸ HTR1D P28221 1/20 0.31
▸ HTR1B P28222 1/20 0.31
▸ FURIN P09958 1/20 0.30
▸ F2 P00734 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24063666 0.78 — —
SCHEMBL11125667 0.76 PRSS1 (0.45) PRSS1PRSS2PRSS3C1SSLC11A2
SCHEMBL1005550 0.76 TDP1 (0.41) —
SCHEMBL27718146 0.73 PRSS1 (0.38) PRSS1PRSS2PRSS3C1SSLC11A2
SCHEMBL2182843 0.72 — —
Hydrochloric Acid SCHEMBL12489365 0.70 KDM4E (0.40) MAPT
SCHEMBL18314954 0.70 PRSS1 (0.61) PRSS1PRSS2PRSS3C1SSLC11A2
SCHEMBL13813419 0.69 SLC9A1 (0.51) —
SCHEMBL1259969 0.68 KDM4E (0.38) —
SCHEMBL625521 0.68 KDM4E (0.48) —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115279804-B Ethylene copolymers and catalyst mixtures for making ethylene copolymers 阿朗新科荷兰有限公司 2024-03-26 — — CN disclosed
CN-111989336-B Metal complexes comprising amidine and indole fused cyclopentadienyl ligands 阿朗新科荷兰有限公司 2023-07-07 — — CN disclosed
US-11189806-B2 Heteroleptic carbene complexes and the use thereof in organic electronics UDC IRELAND LIMITED (IE) 2021-11-30 — — US disclosed
CN-112703208-A Catalyst mixture 阿朗新科荷兰有限公司 2021-04-23 — — CN disclosed
CN-111989336-A Metal complexes comprising amidine and indole fused cyclopentadienyl ligands 阿朗新科荷兰有限公司 2020-11-24 — — CN disclosed
CN-111527095-A Metal complexes comprising amidine and thiophene fused cyclopentadienyl ligands 阿朗新科荷兰有限公司 2020-08-11 — — CN disclosed
CN-107922529-B Catalyst system 阿朗新科荷兰有限公司 2020-05-19 — — CN disclosed
CN-106687468-B Metal complexes comprising amidines and substituted cyclopentadienyl ligands 阿朗新科荷兰有限公司 2020-04-21 — — CN disclosed
US-10543280-B2 Stabilization of biomolecules using sugar polymers THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-01-28 — — US disclosed
EP-2807177-B1 STABILIZATION OF BIOMOLECULES USING SUGAR POLYMERS UNIV CALIFORNIA (US) 2019-11-13 — — EP disclosed
EP-1932834-A1 Aromatic 1,4-DI-Carboxylamides and their use The Genetics Company, Inc. (CH) 2008-06-18 — — EP disclosed
US-20070212299-A1 Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer AGENSYS, INC. (US) 2007-09-13 — — US disclosed
US-7226594-B2 Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer AGENSYS, INC. (US) 2007-06-05 — — US disclosed
EP-1537140-A4 NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 161P2F10B USEFUL IN TREATMENT AND DETECTION OF CANCER AGENSYS INC (US) 2007-03-07 — — EP disclosed
EP-1638588-A1 P-SELECTIN TARGETING LIGAND AND COMPOSITIONS THEREOF Astellas Pharma Inc. (JP) 2006-03-29 — — EP disclosed
EP-1537140-A2 NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 161P2F10B USEFUL IN TREATMENT AND DETECTION OF CANCER Agensys, Inc. (US) 2005-06-08 — — EP disclosed
WO-2004105783-A1 P-SELECTIN TARGETING LIGAND AND COMPOSITIONS THEREOF ASTELLAS PHARMA, INC. (JP) 2004-12-09 — — WO disclosed
US-20030206905-A1 Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer AGENSYS, INC. 2003-11-06 — — US disclosed
WO-2003040340-A9 NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 161P2F10B USEFUL IN TREATMENT AND DETECTION OF CANCER AGENSYS INC (US) 2003-08-07 — — WO disclosed
WO-2003040340-A2 NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 161P2F10B USEFUL IN TREATMENT AND DETECTION OF CANCER AGENSYS, INC. (US) 2003-05-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10543280-B2 Stabilization of biomolecules using sugar polymers TREH, HBG1, SMURF1 PRSS1 1066/4885PRSS2 534/4885PRSS3 422/4885
US-11189806-B2 Heteroleptic carbene complexes and the use thereof in organic electronics OCIAD2, OCIAD1, CLTB PRSS1 3604/4885PRSS2 3248/4885PRSS3 3375/4885
US-20070212299-A1 Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer DCLRE1B, PABPC1, PABPC4 PRSS1 1568/4885PRSS2 2331/4885PRSS3 1889/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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