Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.33 |
| ▸ | ERN1 | O75460 | 5/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.30 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.30 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.30 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29340129 | 0.71 | MAPK1 (0.40) | MAPK1 | |
| SCHEMBL29338952 | 0.67 | BTK (0.37) | BTKMAPK1PDK1 | |
| SCHEMBL29339015 | 0.66 | BTK (0.38) | BTKMAPK1PDK1 | |
| SCHEMBL18765545 | 0.65 | BTK (0.36) | BTKMAPK1PDK1 | |
| SCHEMBL29340146 | 0.65 | BTK (0.36) | BTKPDK1 | |
| SCHEMBL29340337 | 0.65 | BTK (0.43) | BTKERN1MAPK1PDK1 | |
| SCHEMBL18793519 | 0.63 | ERN1 (0.33) | HIF1AERN1 | |
| SCHEMBL18765821 | 0.62 | BTK (0.39) | BTK | |
| SCHEMBL18765757 | 0.61 | MAPK1 (0.52) | MAPK1 | |
| SCHEMBL24853402 | 0.60 | BTK (0.45) | BTKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017068412-A1 | BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-04-27 | — | — | WO | disclosed |