SCHEMBL421340

SCHEMBL421340

COc1ccc(N=C=O)cc1Cl

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.61
MAPK1 P28482 1/20 0.61
ALDH1A1 P00352 6/20 0.46
CYP3A4 P08684 3/20 0.46
HPGD P15428 3/20 0.46
KMT2A Q03164 3/20 0.44
MAPT P10636 2/20 0.44
TRPA1 O75762 1/20 0.44
MEN1 O00255 2/20 0.41
NPC1 O15118 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
SMN1; SMN2 Q16637 3/20 0.38
TP53 P04637 1/20 0.38
PKM P14618 1/20 0.38
NPSR1 Q6W5P4 1/20 0.38
PTGS2 P35354 2/20 0.37
PTGS1 P23219 1/20 0.37
ALOX15 P16050 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL282107 0.86 MAPK1 (0.61) TDP1MAPK1ALDH1A1CYP3A4HPGD
SCHEMBL29600721 0.83 HTR3E (0.53) TDP1MAPK1ALDH1A1CYP3A4HPGD
SCHEMBL307695 0.83 HTR3E (0.53) TDP1MAPK1ALDH1A1CYP3A4HPGD
SCHEMBL11748612 0.82 MAPK1 (0.53) TDP1MAPK1ALDH1A1CYP3A4HPGD
SCHEMBL25271568 0.82 MAPT (0.44) TDP1MAPK1ALDH1A1HPGDKMT2A
SCHEMBL11804851 0.81 MAPK1 (0.56) TDP1MAPK1CYP3A4KMT2ATRPA1
SCHEMBL1428432 0.81 TDP1 (0.56) TDP1MAPK1ALDH1A1CYP3A4HPGD
SCHEMBL11826875 0.80 TDP1 (0.54) TDP1MAPK1ALDH1A1CYP3A4HPGD
SCHEMBL124245 0.80 CYP3A4 (0.59) TDP1MAPK1ALDH1A1CYP3A4HPGD
SCHEMBL29510769 0.80 CYP3A4 (0.59) TDP1MAPK1ALDH1A1CYP3A4HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 156 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240154124-A1 NEGATIVE ELECTRODE PLATE AND LITHIUM-ION BATTERY COMPRISING SAME ZHUHAI COSMX BATTERY CO., LTD. (CN) 2024-05-09 US claimed
CN-116768764-A Process for preparing urea derivatives 安道麦阿甘有限公司 2023-09-19 CN claimed
CN-106008276-A Synthesis method of phenylurea herbicide or deuteration-labeled phenylurea herbicide 湖北出入境检验检疫局检验检疫技术中心 2016-10-12 CN claimed
CN-103614109-A Polyurethane adhesive for package materials SUZHOU SIDIKE NEW MAT SCIENCE & TECHNOLOGY CO LTD 2014-03-05 CN claimed
CN-102618205-B Polyurethane composite adhesive SUZHOU SIDIKE NEW MATERIAL SCIENCE AND TECHNOLOGY CORP 2013-10-30 CN claimed
EP-4667461-A2 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PARKINSON S AND GAUCHER DISEASE Children's Hospital Medical Center (US) 2025-12-24 EP disclosed
US-20250382274-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PARKINSON'S AND GAUCHER DISEASE CHILDRENS HOSPITAL MED CT (US) 2025-12-18 US disclosed
US-12338226-B2 Substituted benzodiazoles and use thereof in therapy THOMAS HELLEDAYS STIFTELSE FOR MEDICINSK FORSKNING (SE) 2025-06-24 US disclosed
US-20240287020-A1 SUBSTITUTED BENZODIAZOLES AND USE THEREOF IN THERAPY THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING (SE) 2024-08-29 US disclosed
US-20240216355-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS MONTE ROSA THERAPEUTICS AG (CH) 2024-07-04 US disclosed
US-20240154124-A1 NEGATIVE ELECTRODE PLATE AND LITHIUM-ION BATTERY COMPRISING SAME ZHUHAI COSMX BATTERY CO., LTD. (CN) 2024-05-09 US disclosed
US-11970474-B2 Substituted benzodiazoles and use thereof in therapy THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING (SE) 2024-04-30 US disclosed
WO-2004096794-A1 AZETIDINECARBOXAMIDE DERIVATIVES AND THEIR USE IN THE TREATMENT OF CB1 RECEPTOR MEDIATED DISORDRS VERNALIS RESEARCH LIMITED (GB) 2004-11-11 WO disclosed
WO-2004048319-A1 NOVEL BENZAMIDE COMPOUNDS FOR USE IN MCH RECEPTOR RELATED DISORDERS 7TM PHARMA A/S (DK) 2004-06-10 WO disclosed
WO-2003087045-A1 NOVEL METHOXYBENZAMIDE COMPOUNDS FOR USE IN MCH RECEPTOR RELATED DISORDERS 7TM PHARMA A/S (DK) 2003-10-23 WO disclosed
EP-0679085-A1 CHEMICAL COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1995-11-02 EP disclosed
US-5378714-A Treatment of depression, anxiety, schizophrenia, affinity for 5HT2 receptors NOVO NORDISK A/S (DK) 1995-01-03 US disclosed
WO-1993010742-A2 CHEMICAL COMPOUNDS, THEIR PREPARATION AND USE NOVO NORDISK A/S (DK) 1993-06-10 WO disclosed
US-3994714-A N-(3-CHLORO-4-METHOXYPHENYL)-N*,N*-DIMETHYLUREA SANDOZ LTD. (CH) 1976-11-30 US disclosed
US-3983172-A HERBICIDES BAYER AKTIENGESELLSCHAFT (DT) 1976-09-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240216355-A1 PHARMACEUTICAL COMPOSITIONS FOR USE IN THE PREVENTION AND TREATMENT OF A DISEASE OR DISORDER CAUSED BY OR ASSOCIATED WITH ONE OR MORE PREMATURE TERMINATION CODONS UPF1, NSUN2, RTF2 TDP1 1868/4885MAPK1 3358/4885ALDH1A1 4150/4885
US-20250382274-A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PARKINSON'S AND GAUCHER DISEASE GBA1, GAA, GBA2 TDP1 504/4885MAPK1 3672/4885ALDH1A1 1073/4885
US-11970474-B2 Substituted benzodiazoles and use thereof in therapy XDH, CYP4X1, CYP11B2 TDP1 1837/4885MAPK1 2175/4885ALDH1A1 330/4885
US-20240287020-A1 SUBSTITUTED BENZODIAZOLES AND USE THEREOF IN THERAPY XDH, CYP11B2, CYP4X1 TDP1 1726/4885MAPK1 1737/4885ALDH1A1 274/4885
US-12338226-B2 Substituted benzodiazoles and use thereof in therapy XDH, CYP11B2, CYP4X1 TDP1 1726/4885MAPK1 1737/4885ALDH1A1 274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.