Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 5/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.37 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18822478 | 0.85 | DRD2 (0.38) | SLC6A9OPRM1SLC6A3HSD11B1GRIN1 | |
| SCHEMBL18794831 | 0.85 | DRD2 (0.38) | SLC6A9OPRM1SLC6A3HSD11B1GRIN1 | |
| SCHEMBL18822477 | 0.85 | DRD2 (0.38) | SLC6A9OPRM1SLC6A3HSD11B1GRIN1 | |
| SCHEMBL18794819 | 0.85 | GRIN1 (0.51) | SLC6A9OPRM1GRIN1GRIN2APOLB | |
| SCHEMBL18794833 | 0.83 | METAP2 (0.38) | GRIN1GRIN2AGRIN2B | |
| SCHEMBL28546096 | 0.80 | GRIN1 (0.43) | GRIN1GRIN2AGRIN2BMAOAMAOB | |
| SCHEMBL18794865 | 0.79 | SLC6A3 (0.46) | SLC6A3GRIN1GRIN2ASLC6A4SLC6A2 | |
| SCHEMBL18794835 | 0.79 | HSD11B1 (0.40) | SLC6A9OPRM1KCNH2SLC6A3HSD11B1 | |
| SCHEMBL18794816 | 0.78 | SLC6A4 (0.42) | KCNH2SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL18794813 | 0.77 | METAP2 (0.41) | GRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017070793-A1 | NOVEL FLUORINATED HETEROCYCLE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2017-05-04 | — | — | WO | claimed |
| WO-2017070793-A1 | NOVEL FLUORINATED HETEROCYCLE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2017-05-04 | — | — | WO | disclosed |
| WO-2017070793-A1 | NOVEL FLUORINATED HETEROCYCLE DERIVATIVES AND THEIR USES AS THERAPEUTIC AGENTS | TRILLIUM THERAPEUTICS INC. (CA) | 2017-05-04 | — | — | WO | disclosed |