SCHEMBL18796088

SCHEMBL18796088

Cc1nc2ccccc2nc1Oc1ccccc1I

nearest known ligand 0.47

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.47
▸ TSHR P16473 1/20 0.47
▸ KDM4E B2RXH2 6/20 0.40
▸ HPGD P15428 1/20 0.40
▸ ALDH1A1 P00352 4/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ POLB P06746 1/20 0.39
▸ LMNA P02545 1/20 0.38
▸ GPR3 P46089 1/20 0.37
▸ NQO2 P16083 4/20 0.37
▸ GAA P10253 1/20 0.37
▸ PDE10A Q9Y233 1/20 0.36
▸ SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24287258 0.81 ALDH1A1 (0.50) L3MBTL1TSHRKDM4EHPGDALDH1A1
SCHEMBL18796404 0.79 LCK (0.52) L3MBTL1TSHRKDM4EHPGDALDH1A1
SCHEMBL16795314 0.79 ALDH1A1 (0.54) L3MBTL1TSHRKDM4EHPGDALDH1A1
SCHEMBL24287256 0.76 L3MBTL1 (0.45) L3MBTL1TSHRKDM4EHPGDALDH1A1
SCHEMBL22372364 0.75 L3MBTL1 (0.47) L3MBTL1TSHRKDM4EHPGDALDH1A1
SCHEMBL804981 0.72 TSHR (0.61) L3MBTL1TSHRKDM4EHPGDALDH1A1
SCHEMBL24287259 0.72 GAA (0.56) L3MBTL1TSHRKDM4EHPGDMAPT
SCHEMBL11401433 0.72 L3MBTL1 (0.74) L3MBTL1TSHRKDM4EHPGDMAPT
SCHEMBL18796221 0.72 L3MBTL1 (0.42) L3MBTL1TSHRKDM4EHPGDALDH1A1
SCHEMBL18796028 0.71 SCD (0.43) L3MBTL1TSHRKDM4EHPGDMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3368514-B1 TRISUBSTITUTED SILYLPHENOXYHETEROCYCLES AND ANALOGUES BAYER CROPSCIENCE AG (DE) 2021-08-18 — — EP disclosed
US-10683311-B2 Trisubstitutedsilylphenoxyheterocycles and analogues BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2020-06-16 — — US disclosed
US-20190233444-A1 TRISUBSTITUTEDSILYLPHENOXYHETEROCYCLES AND ANALOGUES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2019-08-01 — — US disclosed
EP-3368514-A1 TRISUBSTITUTEDSILYLPHENOXYHETEROCYCLES AND ANALOGUES Bayer CropScience Aktiengesellschaft (DE) 2018-09-05 — — EP disclosed
WO-2017072283-A1 TRISUBSTITUTEDSILYLPHENOXYHETEROCYCLES AND ANALOGUES BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) 2017-05-04 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10683311-B2 Trisubstitutedsilylphenoxyheterocycles and analogues PIK3C3, ERG28, DDT L3MBTL1 2453/4885TSHR 4289/4885KDM4E 508/4885
US-20190233444-A1 TRISUBSTITUTEDSILYLPHENOXYHETEROCYCLES AND ANALOGUES PIK3C3, ERG28, DDT L3MBTL1 2453/4885TSHR 4289/4885KDM4E 508/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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