Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 4/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.32 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1879690 | 1.00 | EGFR (0.34) | EGFRKDM4EPOLBALDH1A1L3MBTL1 | |
| SCHEMBL732498 | 0.80 | NFE2L2 (0.39) | L3MBTL1SMN1; SMN2 | |
| SCHEMBL1580085 | 0.79 | EGFR (0.49) | EGFRKDM4EALDH1A1EPHX2NR1H4 | |
| SCHEMBL1580086 | 0.79 | EGFR (0.49) | EGFRKDM4EALDH1A1EPHX2NR1H4 | |
| SCHEMBL1704854 | 0.77 | TBXAS1 (0.49) | EGFRKDM4EALDH1A1L3MBTL1TBXAS1 | |
| SCHEMBL15755442 | 0.77 | TBXAS1 (0.49) | EGFRKDM4EALDH1A1L3MBTL1TBXAS1 | |
| SCHEMBL23722448 | 0.76 | PADI4 (0.32) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL1885751 | 0.74 | — | — | |
| SCHEMBL1768858 | 0.74 | GABRP (0.42) | KDM4EALDH1A1HDAC1HDAC6SMN1; SMN2 | |
| SCHEMBL1768859 | 0.74 | GABRP (0.42) | KDM4EALDH1A1HDAC1HDAC6SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110105474-A1 | HETEROCYCLIC DERIVATIVES AS HDAC INHIBITORS | DAC S.R.L. | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105474-A1 | HETEROCYCLIC DERIVATIVES AS HDAC INHIBITORS | HDAC3, HDAC1, HDAC5 | EGFR 1410/4885KDM4E 142/4885POLB 650/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.